The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, China.
Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Immunol. 2024 Jan 4;14:1264554. doi: 10.3389/fimmu.2023.1264554. eCollection 2023.
Primary biliary cirrhosis (PBC) and psoriasis are frequently observed to co-occur in clinical settings. However, the causal associations and underlying mechanisms between PBC and psoriasis remain poorly defined.
In this study, we conducted bidirectional MR analysis to explore the causal relationship between PBC and psoriasis using four MR methods: inverse-variance weighted, MR-Egger regression, weighted median, and weighted mode. Sensitivity analyses were carried out, employing different models and testing methods for comparison to assess the influence of heterogeneity and pleiotropy on our findings and to confirm the robustness of these results.
A causal relationship between the risk of PBC and psoriasis was identified, as confirmed by IVW analysis (OR: 1.081, 95%CI: 1.0281.137, <0.05). The other three MR methods also produced similar results. However, psoriasis did not have a causal effect on PBC risk (OR: 1.022, 95%CI: 0.9351.118, >0.05). The intercept of MR-Egger regression was 0.0013 (>0.05), indicating that genetic pleiotropy did not influence the results. Additionally, the leave-one-out analysis demonstrated the robustness of our MR findings.
This study reveals a causal relationship between PBC and psoriasis, with PBC increasing the risk of psoriasis, but not the reverse. This potential causal relationship offers a new perspective on the etiology of PBC.
原发性胆汁性肝硬化（PBC）和银屑病常同时在临床中观察到。然而，PBC 和银屑病之间的因果关联和潜在机制仍未得到明确界定。
在这项研究中，我们使用四种 MR 方法（逆方差加权、MR-Egger 回归、加权中位数和加权众数）进行双向 MR 分析，以探索 PBC 和银屑病之间的因果关系。我们进行了敏感性分析，采用不同的模型和检验方法进行比较，以评估异质性和多效性对我们发现的影响，并确认这些结果的稳健性。
IVW 分析证实了 PBC 风险与银屑病之间存在因果关系（OR：1.081，95%CI：1.0281.137，<0.05）。其他三种 MR 方法也得出了相似的结果。然而，银屑病对 PBC 风险没有因果影响（OR：1.022，95%CI：0.9351.118，>0.05）。MR-Egger 回归的截距为 0.0013（>0.05），表明遗传多效性并未影响结果。此外，逐一删除分析证明了我们的 MR 发现具有稳健性。
本研究揭示了 PBC 和银屑病之间存在因果关系，PBC 增加了银屑病的风险，但反之则不然。这种潜在的因果关系为 PBC 的病因学提供了新的视角。
