Zhai Yi-Jie, Zhou Zhen-Zhen, Gao Lin-Lin, Li Jian-Nan, Pescitelli Gennaro, Gao Jin-Ming, Han Wen-Bo
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100 Shaanxi, People's Republic of China.
Provincial Key Laboratory of Agrobiology and Institute of Germplasm Resources and Biotechnology, Jiangsu Academy of Agricultural Sciences, 210014 Nanjing, China.
J Agric Food Chem. 2023 Mar 22;71(11):4615-4624. doi: 10.1021/acs.jafc.2c08710. Epub 2023 Mar 9.
sp., a lichen-associated fungus, produced six skeletally new dimeric spiciferones (-) and four known metabolites (-). The new structures were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Compounds and - represent the first examples of ethylidene-bridged dimers from the building blocks 4-chromene-4,7(8)-dione and α-pyrone, and is a unique homodimer of spiciferone. Compounds , , and - significantly inhibited the growth of weed-like dicot at 100.0 μM. Notably, showed the strongest inhibitory activity against the fresh weight and root elongation of with the IC values of 32.04 and 26.78 μM, respectively, whereas , , and stimulated the growth of at lower concentrations. Meanwhile, compounds and exhibited weak inhibitory effects on the root elongation of monocot rice, while and exhibited growth-promoting effects on the shoot and root elongation of rice in a roughly dose-dependent manner.
一种地衣相关真菌，产生了六种骨架全新的二聚体穗花杉双黄酮（-）和四种已知代谢产物（-）。通过光谱分析阐明了新结构，并通过电子圆二色性计算确定了它们的绝对构型。化合物 和 - 代表了由4-色烯-4,7（8）-二酮和α-吡喃酮构建单元形成的亚乙基桥连二聚体的首个实例，并且 是穗花杉双黄酮的独特同二聚体。化合物 、 和 - 在100.0 μM时显著抑制杂草状双子叶植物的生长。值得注意的是， 对 的鲜重和根伸长表现出最强的抑制活性，IC值分别为32.04和26.78 μM，而 、 和 在较低浓度下刺激了 的生长。同时，化合物 和 对单子叶水稻的根伸长表现出微弱的抑制作用，而 和 对水稻地上部分和根伸长表现出大致剂量依赖性的促进生长作用。
