[母乳喂养对人巨细胞病毒感染婴儿免疫功能的影响]
[Effect of breastfeeding on immune function in infants with human cytomegalovirus infection].
作者信息
Fan Peng-Kai, Xie Xin, Chen Jing, Shi Li-Huan, Guo Ming-Fa, Yang Wei-Li, Liu Wei
机构信息
Children's Hospital Affiliated to Zhengzhou University/Key Laboratory of Pediatric Hematology of Henan Province, Zhengzhou 451161, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Mar 15;25(3):278-283. doi: 10.7499/j.issn.1008-8830.2210103.
OBJECTIVES
To study the effect of breastfeeding on immune function in infants with human cytomegalovirus (HCMV) infection.
METHODS
A retrospective analysis was performed on the medical data of 135 infants with HCMV infection who were admitted to Children's Hospital Affiliated to Zhengzhou University from January 2021 to May 2022, and all these infants received breastfeeding. According to the results of breast milk HCMV-DNA testing, the infants were divided into two groups: breast milk HCMV positive (=78) and breast milk HCMV negative (=57). According to the median breast milk HCMV-DNA load, the infants in the breast milk HCMV positive group were further divided into two subgroups: high viral load and low viral load (=39 each). Related indicators were compared between the breast milk positive and negative HCMV groups and between the breast milk high viral load and low viral load subgroups, including the percentages of peripheral blood lymphocyte subsets (CD3 T cells, CD3CD4 T cells, CD3CD8 T cells, and CD19 B cells), CD4/CD8 ratio, IgG, IgM, IgA, and urine HCMV-DNA load.
RESULTS
There were no significant differences in the percentages of CD3 T cells, CD3CD4 T cells, CD3CD8 T cells, and CD19 B cells, CD4/CD8 ratio, IgG, IgM, IgA, and urine HCMV-DNA load between the breast milk HCMV positive and HCMV negative groups, as well as between the breast milk high viral load and low viral load subgroups (>0.05).
CONCLUSIONS
Breastfeeding with HCMV does not affect the immune function of infants with HCMV infection.
目的
研究母乳喂养对人巨细胞病毒（HCMV）感染婴儿免疫功能的影响。
方法
对2021年1月至2022年5月在郑州大学附属儿童医院住院的135例HCMV感染婴儿的医学资料进行回顾性分析，所有婴儿均接受母乳喂养。根据母乳HCMV-DNA检测结果，将婴儿分为两组：母乳HCMV阳性组（=78例）和母乳HCMV阴性组（=57例）。根据母乳HCMV-DNA载量中位数，母乳HCMV阳性组婴儿进一步分为两个亚组：高病毒载量组和低病毒载量组（各=39例）。比较母乳HCMV阳性和阴性组以及母乳高病毒载量和低病毒载量亚组之间的相关指标，包括外周血淋巴细胞亚群（CD3⁺T细胞、CD3⁺CD4⁺T细胞、CD3⁺CD8⁺T细胞和CD19⁺B细胞）百分比、CD4/CD8比值、IgG、IgM、IgA和尿HCMV-DNA载量。
结果
母乳HCMV阳性组与HCMV阴性组之间以及母乳高病毒载量组与低病毒载量亚组之间，CD3⁺T细胞、CD3⁺CD4⁺T细胞、CD3⁺CD8⁺T细胞和CD19⁺B细胞百分比、CD4/CD8比值、IgG、IgM、IgA和尿HCMV-DNA载量均无显著差异（>0.05）。
结论
感染HCMV的母乳喂养不会影响HCMV感染婴儿的免疫功能。
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