Zheng Ya-Xin, Jiang Li
Department of Neurology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Mar 15;25(3):321-327. doi: 10.7499/j.issn.1008-8830.2211125.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune inflammatory disease of the central nervous system, and little is known about its immune mechanism at present. There is a lack of disease-related biomarkers in cerebrospinal fluid except anti-NMDAR antibody, which leads to delayed diagnosis and treatment in some patients. Therefore, there has been an increasing number of studies on related cytokines in recent years to assess whether they can be used as new biomarkers for evaluating disease conditions and assisting diagnosis and treatment. Current studies have shown that some cytokines may be associated with the progression of anti-NMDAR encephalitis, and this article reviews the research advances in such cytokines associated with anti-NMDAR encephalitis.
抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎是一种中枢神经系统自身免疫性炎症性疾病，目前对其免疫机制知之甚少。除抗NMDAR抗体外，脑脊液中缺乏疾病相关生物标志物，这导致部分患者诊断和治疗延迟。因此，近年来对相关细胞因子的研究越来越多，以评估它们是否可作为评估病情及辅助诊断和治疗的新生物标志物。目前的研究表明，一些细胞因子可能与抗NMDAR脑炎的进展有关，本文综述了与抗NMDAR脑炎相关的此类细胞因子的研究进展。
