Rodrigues Schneider Lara, da Silva Barboza Andressa, Ribeiro de Andrade Juliana Silva, Coelho Dos Santos Daniela, Cuevas-Suárez Carlos Enrique, Piva Evandro, Campos Angela Diniz, Lund Rafael Guerra
Post-Graduate Program in Biochemistry and Bioprospection, Laboratory of Oral Microbiology, Pelotas Dental School, Federal University of Pelotas, Pelotas, RS, Brazil.
Post-Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Pelotas, RS, Brazil.
Biofouling. 2023 Jan;39(1):110-120. doi: 10.1080/08927014.2023.2189012. Epub 2023 Mar 22.
This study aimed to evaluate the antimicrobial activity and physicochemical properties of a novel dual-cure endodontic sealer containing copaiba oil. The copaiba oil was obtained and characterized by gas chromatography (GC), and the minimum inhibitory concentration (MIC) was performed. The experimental sealers were formulated with copaiba oil concentrations of 0, 0.5, 1, and 2%, and the RealSeal™ (Sybron endo, Orange, USA) and AH Plus (Dentsply De Trey Gmbh, Konstanz, Germany) were used as the commercial references. The antimicrobial activity of the sealers was evaluated by the direct contact test for 1h and 24h. To evaluate the physicochemical properties of the sealers, the degree of conversion, setting time, film thickness, dimensional stability, and radiopacity tests were performed. The data were statistically analyzed by one-way ANOVA and Tukey's test (α = 0.05). Concerning the results, the sealers containing copaiba oil showed antimicrobial activity without harming the physicochemical properties.
本研究旨在评估一种含苦配巴油的新型双固化根管封闭剂的抗菌活性和理化性质。获取苦配巴油并通过气相色谱（GC）对其进行表征，同时测定最低抑菌浓度（MIC）。实验性封闭剂的配方中苦配巴油浓度分别为0%、0.5%、1%和2%，并选用RealSeal™（美国西邦公司，奥兰治）和AH Plus（德国登士柏德特雷公司，康斯坦茨）作为商业对照品。通过直接接触试验评估封闭剂在1小时和24小时时的抗菌活性。为评估封闭剂的理化性质，进行了转化率、凝固时间、膜厚度、尺寸稳定性和射线不透性测试。数据采用单因素方差分析和Tukey检验进行统计学分析（α = 0.05）。关于结果，含苦配巴油的封闭剂显示出抗菌活性，且未损害其理化性质。
