Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of pathology, Faculty of Medicine, Assiut University, Egypt.
Dermatol Surg. 2023 Jun 1;49(6):552-558. doi: 10.1097/DSS.0000000000003763. Epub 2023 Mar 21.
Striae distensae (SD) or stretch marks are common cutaneous conditions that occur because of the stretching of the dermis.OBJECTIVE To evaluate and compare the efficacy of fractional carbon dioxide (CO 2 ) laser alone versus combined fractional CO 2 laser with platelet-rich plasma (PRP) in SD treatment.
Thirty adult female patients with SD (SR and SA) were enrolled. In each patient, a split-lesion design was conducted as follows: pairs of SD on both sides of the midline were selected and allocated to groups A and B. Group A: was treated with combined fractional CO 2 laser with intradermal PRP. Group B: was treated with fractional CO 2 laser alone. Skin biopsies were taken from the lesions before and after treatment for histopathologic evaluation.
In group A, a significant excellent improvement of the SD was achieved more than in group B ( p = .007) and the mean of improvement was significantly higher (60.33 ± 26.49) than that in group B (43.80 ± 27.43) ( p -value = .001). Group A was also associated with a more significant dermal deposition of collagen and elastic fibers.
Combined fractional CO 2 laser with PRP was more effective than fractional CO 2 laser alone for the treatment of SD.
妊娠纹（SD）或伸展纹是常见的皮肤状况，由于真皮的拉伸而发生。
评估和比较单纯分馏二氧化碳（CO 2 ）激光与联合富血小板血浆（PRP）治疗 SD 的疗效。
招募了 30 名 SD（SR 和 SA）成年女性患者。在每位患者中，均进行了皮损分割设计，如下所示：中线两侧的一对 SD 被选入 A 组和 B 组。A 组：接受联合真皮内 PRP 的分馏 CO 2 激光治疗。B 组：接受单纯分馏 CO 2 激光治疗。治疗前后从病变部位取皮肤活检进行组织病理学评估。
A 组 SD 的显著改善程度明显高于 B 组（p=0.007），且改善的平均值（60.33±26.49）明显高于 B 组（43.80±27.43）（p 值=0.001）。A 组真皮中胶原和弹性纤维的沉积也更为显著。
与单纯分馏 CO 2 激光相比，联合 PRP 的分馏 CO 2 激光治疗 SD 更为有效。
