Physiology Department, Danylo Halytsky Lviv National Medical University, 69 Pekarska Str, Lviv, 79010, UA, Ukraine.
Internal Diseases, CNE "Novoiavorivsk District Hospital Named After Yuri Lypa" Lviv Region, Novoiavorivsk, 81053, UA, Ukraine.
Inflammopharmacology. 2023 Apr;31(2):597-602. doi: 10.1007/s10787-023-01177-1. Epub 2023 Mar 22.
Multifaceted long COVID caused by SARS-COV-2 affects all populations in the World and takes priority over any other research topics for health care. The purpose of study is to identify physiology-centered risks, prevalence, symptoms and laboratory findings in patients with long COVID in Ukraine.
A prospective, cohort study was carried out on 332 patients with long COVID after 4 weeks and more after acute infection COVID-19 from Jul 1, 2021, to Jul 1, 2022. Physiology-centered risks related to age, gender, body mass index (BMI), marital status and educational capacity, smoking, lifestyle, physical activity, and laboratory findings (before disease), and symptom distribution were analyzed.
The cohort for the study consisted of 166 females and 107 males (mean age = 42; including young 18 (5.4%) and middle- and old-aged adults 314 (96.4%)). Increased BMI was in 61%, and less physical activity-65%. There were 4 clusters of symptoms related to physical, neurocognitive, pulmonary, and pain conditions. 95% of participants had ≥ 3 symptoms. The most common symptoms were fatigue (90%), muscular pain (85%), anosmia (70%), hair loss (70%), sleep disorders (70%), dyspnea (30%), and brain fog (25%). Among laboratory finding increased CRP (92.6%) and fibrinogen (82.7%) dominated. There are no differences between hospitalized and non-hospitalized patients in distribution symptoms.
The prevalence of long COVID is 23%, and its physiology-centered risk factors are related to age more 38 years, female sex, unhealthy lifestyle, increased BMI, and increased inflammatory markers during COVID-19. The most common symptoms are associated with neurocognitive and pain clusters.
由 SARS-COV-2 引起的多方面长新冠影响全球所有人群，并优先于任何其他医疗保健研究课题。本研究旨在确定乌克兰长新冠患者的以生理学为中心的风险、流行率、症状和实验室检查结果。
这是一项前瞻性队列研究，纳入了 2021 年 7 月 1 日至 2022 年 7 月 1 日期间急性感染 COVID-19 4 周及以上的 332 例长新冠患者。分析了与年龄、性别、体重指数（BMI）、婚姻状况和教育能力、吸烟、生活方式、体力活动以及（发病前）实验室检查结果相关的以生理学为中心的风险，以及症状分布情况。
研究队列包括 166 名女性和 107 名男性（平均年龄 42 岁；包括 18 名年轻患者[5.4%]和 314 名中老年患者[96.4%]）。BMI 增加的占 61%，体力活动减少的占 65%。存在与躯体、神经认知、肺部和疼痛状况相关的 4 个症状簇。95%的患者有≥3 个症状。最常见的症状是疲劳（90%）、肌肉疼痛（85%）、嗅觉丧失（70%）、脱发（70%）、睡眠障碍（70%）、呼吸困难（30%）和大脑雾感（25%）。实验室检查发现，CRP（92.6%）和纤维蛋白原（82.7%）升高为主。住院与非住院患者的症状分布无差异。
长新冠的流行率为 23%，其以生理学为中心的危险因素与 38 岁以上、女性、不健康的生活方式、BMI 增加以及 COVID-19 期间炎症标志物增加有关。最常见的症状与神经认知和疼痛簇有关。
