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Targeting Mutations in Advanced Melanoma.

作者信息

Phadke Manali S, Smalley Keiran S M

机构信息

Department of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL.

Department of Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL.

出版信息

J Clin Oncol. 2023 May 10;41(14):2661-2664. doi: 10.1200/JCO.23.00205. Epub 2023 Mar 22.

DOI:10.1200/JCO.23.00205
PMID:36947724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10414701/
Abstract
摘要

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本文引用的文献

1
Initial Evidence for the Efficacy of Naporafenib in Combination With Trametinib in -Mutant Melanoma: Results From the Expansion Arm of a Phase Ib, Open-Label Study.NAPORAFENIB 联合曲美替尼治疗 - 突变型黑色素瘤的初步疗效证据：一项 Ib 期、开放标签研究扩展臂的结果。
J Clin Oncol. 2023 May 10;41(14):2651-2660. doi: 10.1200/JCO.22.02018. Epub 2023 Mar 22.
2
Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced -Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134.达拉非尼联合曲美替尼对比纳武利尤单抗联合伊匹木单抗治疗晚期-突变型黑色素瘤患者：DREAMseq 试验-ECOG-ACRIN EA6134。
J Clin Oncol. 2023 Jan 10;41(2):186-197. doi: 10.1200/JCO.22.01763. Epub 2022 Sep 27.
3
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.NRAS 突变体能增强黑色素瘤起始过程中的 BRAF 结合。
Nat Commun. 2022 Jun 7;13(1):3153. doi: 10.1038/s41467-022-30881-9.
4
Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma.Ribociclib 联合 Binimetinib 治疗NRAS 突变型黑色素瘤患者的 Ib/II 期临床试验。
Clin Cancer Res. 2022 Jul 15;28(14):3002-3010. doi: 10.1158/1078-0432.CCR-21-3872.
5
NRAS mutant melanoma: Towards better therapies.NRAS 突变型黑色素瘤：迈向更好的治疗方法。
Cancer Treat Rev. 2021 Sep;99:102238. doi: 10.1016/j.ctrv.2021.102238. Epub 2021 May 29.
6
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Cancer Immunol Res. 2021 May;9(5):554-567. doi: 10.1158/2326-6066.CIR-20-0905. Epub 2021 Mar 2.
8
LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.LXH254，一种强效和选择性的 ARAF spared BRAF 和 CRAF 抑制剂，用于治疗 MAPK 驱动的肿瘤。
Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. doi: 10.1158/1078-0432.CCR-20-2563. Epub 2020 Dec 22.
9
KRAS Inhibition with Sotorasib in Advanced Solid Tumors.索托拉西布治疗晚期实体瘤的 KRAS 抑制作用。
N Engl J Med. 2020 Sep 24;383(13):1207-1217. doi: 10.1056/NEJMoa1917239. Epub 2020 Sep 20.
10
E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms.E2F 报告揭示了 MEK1/2-CDK4/6 靶向和 mTOR-S6 耐药机制的有效方案。
Cancer Discov. 2018 May;8(5):568-581. doi: 10.1158/2159-8290.CD-17-0699. Epub 2018 Mar 1.