新冠病毒奥密克戎变异株在呼吸活动中的脱落情况。

SARS-CoV-2 Omicron variant shedding during respiratory activities.

机构信息

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.

National Centre for Infectious Diseases, Singapore; Tan Tock Seng Hospital, Singapore; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

出版信息

Int J Infect Dis. 2023 Jun;131:19-25. doi: 10.1016/j.ijid.2023.03.029. Epub 2023 Mar 21.

DOI:10.1016/j.ijid.2023.03.029

PMID:36948451

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10028358/

Abstract

OBJECTIVES

As the world transitions to COVID-19 endemicity, studies focusing on aerosol shedding of highly transmissible SARS-CoV-2 variants of concern (VOCs) are vital for the calibration of infection control measures against VOCs that are likely to circulate seasonally. This follow-up Gesundheit-II aerosol sampling study aims to compare the aerosol shedding patterns of Omicron VOC samples with pre-Omicron variants analyzed in our previous study.

DESIGN

Coarse and fine aerosol samples from 47 patients infected with SARS-CoV-2 were collected during various respiratory activities (passive breathing, talking, and singing) and analyzed using reverse transcription-quantitative polymerase chain reaction and virus culture.

RESULTS

Compared with patients infected with pre-Omicron variants, comparable SARS-CoV-2 RNA copy numbers were detectable in aerosol samples of patients infected with Omicron despite being fully vaccinated. Patients infected with Omicron also showed a slight increase in viral aerosol shedding during breathing activities and were more likely to have persistent aerosol shedding beyond 7 days after disease onset.

CONCLUSION

This follow-up study reaffirms the aerosol shedding properties of Omicron and should guide continued layering of public health interventions even in highly vaccinated populations.

摘要

目的

随着世界向 COVID-19 地方性过渡，研究重点关注高传染性 SARS-CoV-2 变体（VOC）的气溶胶释放对于针对可能季节性传播的 VOC 校准感染控制措施至关重要。这项后续的 Gesundheit-II 气溶胶采样研究旨在比较奥密克戎 VOC 样本与我们之前研究中分析的前奥密克戎变体的气溶胶释放模式。