Division of Hematology/Oncology, Kanagawa Children's Medical Center, Japan.
Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohamashi Tobu Hospital, Japan.
Intern Med. 2023 Jun 15;62(12):1813-1816. doi: 10.2169/internalmedicine.1308-22. Epub 2023 Mar 22.
We herein report a case of hepatitis-associated aplastic anemia (HAAA) that occurred after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. In this patient, progressive pancytopenia observed two months after acute hepatitis following the second dose of the SARS-CoV-2 vaccine indicated the development of HAAA. Although some reports have suggested that SARS-CoV-2 vaccination may be involved in the development of autoimmune diseases, no cases of HAAA developing after SARS-CoV-2 vaccination have been reported. SARS-CoV-2 vaccination in children has only started relatively recently, so the range of side effects in children has not yet been thoroughly described. Therefore, we need to strengthen surveillance for symptoms of children who are vaccinated.
我们在此报告一例在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗接种后发生的肝炎相关性再生障碍性贫血（HAAA）病例。在该患者中，第二剂 SARS-CoV-2 疫苗接种后急性肝炎两个月后观察到进行性全血细胞减少，提示发生 HAAA。尽管一些报告表明 SARS-CoV-2 疫苗接种可能与自身免疫性疾病的发生有关，但尚未有 SARS-CoV-2 疫苗接种后发生 HAAA 的病例报告。儿童中 SARS-CoV-2 疫苗接种最近才开始，因此儿童的副作用范围尚未得到充分描述。因此，我们需要加强对接种疫苗儿童症状的监测。
