First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Division of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Public Health. 2023 Mar 6;11:1021378. doi: 10.3389/fpubh.2023.1021378. eCollection 2023.
It is reported that insulin resistance widely exists in non-diabetic patients with a recent history of transient ischemic attack (TIA) or ischemic stroke. There is currently strong evidence to prove the bidirectional effect of glucose metabolism disorders and stroke events. Therefore, it is necessary to retrospectively tease out the current status, hotspots, and frontiers of insulin resistance and ischemic cerebrovascular disease through CiteSpace.
We searched the Web of Science (WOS) for studies related to insulin resistance and ischemic cerebrovascular disease from 1999 to April 2022, then downloaded the data into CiteSpace to generate a knowledge visualization map.
A total of 1,500 publications relevant to insulin resistance and ischemic cerebrovascular disease were retrieved. The USA had the most articles on this topic, followed by PEOPLES R CHINA and JAPAN. WALTER N KERNAN was the most prolific author, whose research mainly focused on insulin resistance intervention after stroke (IRIS) trial. The most common keywords were myocardial ischemia, metabolic syndrome, ischemic stroke, cerebral ischemia, association, oxidative stress, inflammation, and adipose tissue. Major ongoing research trends include three aspects: (1) the association between insulin resistance and ischemic cerebrovascular disease in non-diabetic patients, (2) the intrinsic pathological mechanism between insulin resistance and ischemic cerebrovascular disease, and (3) early intervention of insulin resistance to improve the prognosis of stroke.
The results of this bibliometric study provide the current status and trends of clinical research publications in the field of insulin resistance and ischemic cerebrovascular disease. Insulin resistance is strongly associated with the occurrence of ischemic stroke, early neurological deterioration in stroke patients, post-stroke depression, and cerebral small vessel disease. Early treatment of insulin resistance can be an effective way to prevent the onset of ischemic stroke and improve stroke prognosis. This study may help researchers to identify hot topics and explore new research directions.
有报道称，近期有短暂性脑缺血发作（TIA）或缺血性脑卒中病史的非糖尿病患者普遍存在胰岛素抵抗。目前有强有力的证据证明葡萄糖代谢紊乱和卒中事件之间存在双向作用。因此，有必要通过 CiteSpace 回顾性梳理胰岛素抵抗与缺血性脑血管病的现状、热点和前沿。
我们检索了 1999 年至 2022 年 4 月期间与胰岛素抵抗和缺血性脑血管病相关的 Web of Science（WOS）研究，然后将数据下载到 CiteSpace 中以生成知识可视化图谱。
共检索到 1500 篇与胰岛素抵抗和缺血性脑血管病相关的文献。美国在该主题上的文章最多，其次是中国和日本。沃尔特·N·克南（Walter N Kernan）是最有影响力的作者，他的研究主要集中在卒中后胰岛素抵抗干预（IRIS）试验上。最常见的关键词是心肌缺血、代谢综合征、缺血性脑卒中、脑缺血、关联、氧化应激、炎症和脂肪组织。主要的研究趋势包括三个方面：（1）非糖尿病患者胰岛素抵抗与缺血性脑血管病的相关性，（2）胰岛素抵抗与缺血性脑血管病之间的内在病理机制，（3）胰岛素抵抗的早期干预改善卒中预后。
本计量学研究的结果提供了胰岛素抵抗和缺血性脑血管病领域临床研究文献的现状和趋势。胰岛素抵抗与缺血性卒中的发生、卒中患者早期神经恶化、卒中后抑郁和脑小血管疾病密切相关。早期治疗胰岛素抵抗可能是预防缺血性卒中发作和改善卒中预后的有效方法。本研究可能有助于研究人员识别热点并探索新的研究方向。
