He Shiming, Kuang Yinghao, Huang Xinfang, Jian Yafei, Zhang Jinyan, Huang Wanfen, Zou Yang, Sheng Guotai, Wang Wei, Yang Hongyi
Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China.
Lipids Health Dis. 2025 Jul 17;24(1):243. doi: 10.1186/s12944-025-02667-7.
Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI).
A total of 4,718 participants without baseline stroke history were included in this investigation, with new-onset stroke cases identified as the main study outcome. Cumulative exposure to the TyG-WWI was calculated based on repeated measurement data from the first and third waves of the national surveys. The relationships of TyG-WWI and CumTyG-WWI with stroke risk were examined using multivariable Cox regression, followed by validation in sensitivity analyses.
Within a six-year median tracking period, 350 cases of stroke were documented among the research subjects. Following adjustment for confounding variables, the Cox regression analysis indicated progressively higher stroke risk with increasing TyG-WWI or CumTyG-WWI levels. Multiple sensitivity analyses further confirmed the robustness of these findings. Additionally, subgroup analysis results demonstrated significant differences in stroke risk associated with TyG-WWI and CumTyG-WWI across different age strata; specifically, individuals aged 45-59 years had a relatively higher stroke risk at similarly high levels of TyG-WWI and CumTyG-WWI compared to those aged ≥ 60 years.
Elevated baseline TyG-WWI was significantly associated with increased stroke risk. Moreover, the increasing cumulative exposure of TyG-WWI over time further elevates the risk of stroke occurrence.
胰岛素抵抗和肥胖是导致中风发病率的重要因素。本研究探讨中风风险与甘油三酯葡萄糖-体重调整腰围指数（TyG-WWI，胰岛素抵抗和肥胖的综合标志物）及其累积暴露量（CumTyG-WWI）之间的关联。
本研究共纳入4718名无基线中风病史的参与者，将新发中风病例确定为主要研究结局。基于全国调查第一波和第三波的重复测量数据计算TyG-WWI的累积暴露量。使用多变量Cox回归分析TyG-WWI和CumTyG-WWI与中风风险的关系，随后在敏感性分析中进行验证。
在六年的中位随访期内，研究对象中有350例中风病例被记录。在对混杂变量进行调整后，Cox回归分析表明，随着TyG-WWI或CumTyG-WWI水平的升高，中风风险逐渐增加。多项敏感性分析进一步证实了这些发现的稳健性。此外，亚组分析结果显示，不同年龄层中与TyG-WWI和CumTyG-WWI相关的中风风险存在显著差异；具体而言，与≥60岁的个体相比，45-59岁的个体在TyG-WWI和CumTyG-WWI水平相似时中风风险相对较高。
基线TyG-WWI升高与中风风险增加显著相关。此外，随着时间的推移，TyG-WWI累积暴露量的增加会进一步提高中风发生的风险。
