Patil Amruta Ashok, Patil Purwa, Walke Vaishali
Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Sangli, India.
Department of Pathology, Grant Medical College, Mumbai, Maharashtra, India.
J Midlife Health. 2022 Jul-Sep;13(3):254-256. doi: 10.4103/jmh.jmh_32_21. Epub 2023 Jan 14.
Lymphocytic hypophysitis (LYH) is a rare inflammatory disease in which lymphoplasmacytic infiltration of the pituitary gland can potentially lead to panhypopituitarism. This entity was first recognized in 1962 by Goudie and Pinkerton. We report the case of a 36-year-old nonpregnant female operated for a presumed nonsecreting pituitary adenoma. On intraoperative squash cytology and histology of excision biopsy confirmed the diagnosis of LYH. Review of the literature shows that most reported cases have occurred in women during pregnancy or during postpartum period. Many were accurately diagnosed only after biopsy or at necropsy. It is suspected to be an autoimmune endocrinopathy as concomitant lymphocytic infiltration of the thyroid and pituitary glands has been noted and antipituitary antibodies have been found in some instances. Clinically and radiologically, LYH may mimic a nonsecretory pituitary adenoma. Intraoperative diagnosis may prevent unnecessary excision of potentially functioning pituitary.
淋巴细胞性垂体炎（LYH）是一种罕见的炎症性疾病，其中垂体的淋巴浆细胞浸润可能会导致全垂体功能减退。该病症于1962年由古迪（Goudie）和平克顿（Pinkerton）首次确认。我们报告了一例36岁未孕女性的病例，该女性因疑似无分泌功能的垂体腺瘤接受手术。术中压片细胞学检查及切除活检的组织学检查确诊为淋巴细胞性垂体炎。文献回顾表明，大多数报道的病例发生于孕期或产后的女性。许多病例仅在活检后或尸检时才得到准确诊断。由于已注意到甲状腺和垂体同时存在淋巴细胞浸润，且在某些情况下发现了抗垂体抗体，因此怀疑它是一种自身免疫性内分泌病。在临床和放射学上，淋巴细胞性垂体炎可能类似于无分泌功能的垂体腺瘤。术中诊断可避免对可能有功能的垂体进行不必要的切除。
