急性中心性浆液性脉络膜视网膜病变患者血清纤维蛋白原/白蛋白比值升高。
Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy.
作者信息
Limon Utku, Bozkurt Erdinç, Bulut Sinan, Ilkay Betül, Akçay Sezgin
机构信息
448249University of Health Sciences Umraniye Training and Research Hospital Eye Clinic Istanbul, Turkey.
出版信息
Eur J Ophthalmol. 2022 May;32(3):1735-1742. doi: 10.1177/11206721221089773. Epub 2022 Mar 21.
PURPOSE
To evaluate the serum fibrinogen/albumin ratios in patients with acute and chronic central serous chorioretinopathy, and healthy control samples.
METHODS
Serum fibrinogen/albumin ratios were assessed in patients with acute (Group-1, 30 eyes) and chronic (Group-2, 30 eyes) central serous chorioretinopathy, and compared with healthy control (Group-3, 30 eyes) samples.
RESULTS
Fibrinogen/albumin ratios were significantly higher in Group-1 (104.72 ± 12.34) than in Group-2 (75.83 ± 10.06) and in Group-3 (72 ± 9.54) ( = 0.001). No significant correlation was found between age, CMT, and BCVA with fibrinogen/albumin ratios in the Pearson correlation analysis. In the ROC curve analysis, the most appropriate cut-off value of the fibrinogen/albumin ratio for acute CSCR was ≥87.8 and the optimal cut-off value for the fibrinogen/albumin ratio for chronic CSCR was ≥68.6.
CONCLUSION
The fibrinogen/albumin ratio may be useful as an inflammatory biomarker to monitor the systemic inflammatory state during the treatment and follow-up in patients with acute CSCR.
目的
评估急性和慢性中心性浆液性脉络膜视网膜病变患者以及健康对照样本的血清纤维蛋白原/白蛋白比值。
方法
对急性中心性浆液性脉络膜视网膜病变患者（第1组，30只眼）和慢性中心性浆液性脉络膜视网膜病变患者（第2组，30只眼）的血清纤维蛋白原/白蛋白比值进行评估，并与健康对照（第3组，30只眼）样本进行比较。
结果
第1组（104.72±12.34）的纤维蛋白原/白蛋白比值显著高于第2组（75.83±10.06）和第3组（72±9.54）（P = 0.001）。在Pearson相关性分析中，年龄、中心凹下脉络膜厚度（CMT）和最佳矫正视力（BCVA）与纤维蛋白原/白蛋白比值之间未发现显著相关性。在ROC曲线分析中，急性中心性浆液性脉络膜视网膜病变的纤维蛋白原/白蛋白比值最合适的截断值≥87.8，慢性中心性浆液性脉络膜视网膜病变的纤维蛋白原/白蛋白比值的最佳截断值≥68.6。
结论
纤维蛋白原/白蛋白比值可能作为一种炎症生物标志物，用于监测急性中心性浆液性脉络膜视网膜病变患者治疗和随访期间的全身炎症状态。
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