Majaliwa Edna Siima, Muze Kandi Catherine, Ndayongeje Joel, Mfinanga Sayoki Geofrey, Mmbaga Blandina Theophil, Ramaiya Kaushik
Kilimanjaro Christian Medical University College, Moshi, United Republic of Tanzania.
Muhimbili National Hospital, Dar es Salaam, United Republic of Tanzania.
Glob Pediatr Health. 2023 Mar 18;10:2333794X231159790. doi: 10.1177/2333794X231159790. eCollection 2023.
Type 1 diabetes mellitus (T1DM) complications corelate with C-peptide levels. However, the C-Peptide role has not been explored in resource limited countries. This study explored the relationship between C-peptide and complications. A cross-sectional study involving participants aged 0 to 25 years with T1DM in Dar es salaam Tanzania, between 2021 and 2022 was done. Diabetes nephropathy and retinopathy were assessed. About 281 (92.4%) participants were screened, 144 (51.2%) were females. Mean age was 19 ± 6 years. Majority 175 (62.3%) had poor glycemic control (HbA1c) > 10%, and low C-Peptide level 201 (71.5%). Retinopathy was 11.7% and risk for nephropathy was 41.3%. About 13.4% and 41.8% with low C peptide had Retinopathy and high-risk nephropathy respectively. Age at diagnosis, poor glycemic control, low c peptide and duration of diabetes were associated with complications. Further prospective studies are needed to capture when complications set in, so to have better strategies to prevent complications.
1型糖尿病（T1DM）并发症与C肽水平相关。然而，在资源有限的国家，C肽的作用尚未得到探讨。本研究探讨了C肽与并发症之间的关系。2021年至2022年期间，在坦桑尼亚达累斯萨拉姆对0至25岁的T1DM患者进行了一项横断面研究。评估了糖尿病肾病和视网膜病变。约281名（92.4%）参与者接受了筛查，其中144名（51.2%）为女性。平均年龄为19±6岁。大多数175名（62.3%）患者血糖控制不佳（糖化血红蛋白>10%），C肽水平较低者201名（71.5%）。视网膜病变发生率为11.7%，肾病风险为41.3%。C肽水平低的患者中，分别有13.4%和41.8%患有视网膜病变和高风险肾病。诊断年龄、血糖控制不佳、C肽水平低和糖尿病病程与并发症相关。需要进一步开展前瞻性研究，以确定并发症何时出现，从而制定更好的并发症预防策略。
