Guildford Lynda, Crofts Catherine, Lu Jun
School of Public Health and Interdisciplinary Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 0627, New Zealand.
School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand.
Biomedicines. 2020 May 3;8(5):108. doi: 10.3390/biomedicines8050108.
Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2-5minutes). It is theorised that c-peptide levels (half-life 20-30minutes) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph's Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a fourhour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson's correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482-0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia.
高胰岛素血症是众多代谢紊乱的先兆。早期诊断和干预可改善人群健康状况。由于胰岛素的半衰期非常短（2 - 5分钟），因此诊断高胰岛素血症存在问题。从理论上讲，由于两种激素以等摩尔量释放，所以C肽水平（半衰期20 - 30分钟）可能是胰岛素更好的替代指标。然而，C肽与胰岛素水平之间的相关性尚不清楚。我们旨在通过四小时口服葡萄糖耐量试验（OGTT）来确定它们之间的相关性。数据来自美国伊利诺伊州芝加哥市圣约瑟夫医院1977年的常规医疗记录。255名年龄超过20岁的男性和女性参与者进行了四小时的OGTT，并记录了血糖、胰岛素和C肽水平。使用皮尔逊相关性评估相关性。胰岛素与C肽之间存在弱相关性，在四小时的OGTT过程中这种相关性增强至中度（r = 0.482 - 0.680）。根据世界卫生组织的血糖状态或克拉夫特胰岛素反应对数据进行细分时，这种关系没有显著变化。虽然胰岛素和C肽之间存在相关性，但这种相关性太弱，不足以推荐使用C肽作为诊断高胰岛素血症的替代生物标志物。
