Çakırca Tuba Damar, Çakırca Gökhan, Torun Ayşe, Bindal Ahmet, Üstünel Murat, Kaya Ahmet
Tuba Damar Çakırca, Department of Infectious Diseases and Clinical Microbiology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey.
Gökhan Çakırca, Department of Biochemistry, Sanliurfa Mehmet Akif Inan, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.
Pak J Med Sci. 2023 Mar-Apr;39(2):450-455. doi: 10.12669/pjms.39.2.6856.
To examine the relationship between COVID-19 severity and procalcitonin/albumin ratio (PAR) and compare the PAR with oft-reported inflammatory markers, including procalcitonin, white blood cell (WBC), neutrophil/lymphocyte ratio (NLR) and C-reactive protein (CRP).
In this retrospective research study conducted at Sanliurfa Training and Research Hospital during May to September 2020; total, 577 adult subjects diagnosed with COVID-19 were included and categorized into two groups based on place of hospitalization: the intensive care unit (ICU) group (n=151) and the general ward (GW) group (n=426). Laboratory test results and demographic characteristics of the subjects were recorded.
PAR, NLR, CRP, WBC, neutrophil and procalcitonin values were markedly higher in the ICU group than in the GW group. On the contrary, lymphocyte count and albumin level were markedly lower. PAR showed positive correlations with WBC, NLR, and CRP. Multivariate analysis showed that advanced age, presence of hypertension, elevated PAR, WBC, NLR, urea and lactate dehydrogenase levels were independent risk factors associated with the need for intensive care in COVID-19 subjects. Among them, the PAR showed the highest odds ratio (5.564) for ICU admission. Additionally, the area under the ROC curve of the PAR (0.888) was markedly greater than that of WBC (0.777), NLR (0.822), CRP (0.842) and procalcitonin (0.870).
This study revealed that PAR was superior to procalcitonin, WBC, NLR and CRP in determining COVID-19 severity. PAR was an important predictor of ICU requirement in COVID-19 cases.
探讨新型冠状病毒肺炎（COVID-19）严重程度与降钙素原/白蛋白比值（PAR）之间的关系，并将PAR与常用的炎症标志物进行比较，这些标志物包括降钙素原、白细胞（WBC）、中性粒细胞/淋巴细胞比值（NLR）和C反应蛋白（CRP）。
本回顾性研究于2020年5月至9月在尚勒乌尔法培训与研究医院开展；共纳入577例确诊为COVID-19的成年患者，并根据住院地点分为两组：重症监护病房（ICU）组（n = 151）和普通病房（GW）组（n = 426）。记录患者的实验室检查结果和人口统计学特征。
ICU组的PAR、NLR、CRP、WBC、中性粒细胞和降钙素原值显著高于GW组。相反，淋巴细胞计数和白蛋白水平显著较低。PAR与WBC、NLR和CRP呈正相关。多因素分析显示，高龄、高血压、PAR升高、WBC、NLR、尿素和乳酸脱氢酶水平升高是COVID-19患者需要重症监护的独立危险因素。其中，PAR显示入住ICU的比值比最高（5.564）。此外，PAR的ROC曲线下面积（0.888）显著大于WBC（0.777）、NLR（0.822）、CRP（0.842）和降钙素原（0.870）。
本研究表明，PAR在判断COVID-19严重程度方面优于降钙素原、WBC、NLR和CRP。PAR是COVID-19病例中入住ICU的重要预测指标。
