Tahir Maliha, Mehmood Ramlah, Ahmad Mirza Sultan
Dr. Maliha Tahir, MBBS., King Edward Medical, University, Lahore, Pakistan. Medical Officer Pediatric, Department of Paediatrics Fazl-e-Omar Hospital, Chenab Nagar, District Chiniot, Pakistan.
Dr. Ramlah Mehmood, MBBS, FCPS (Pediatrics)., Consultant Pediatrician, Department of Paediatrics Fazl-e-Omar Hospital, Chenab Nagar, District Chiniot, Pakistan.
Pak J Med Sci. 2023 Mar-Apr;39(2):616-618. doi: 10.12669/pjms.39.2.6359.
Kawasaki disease is a generalized systemic vasculitis that affects blood vessels throughout the body. The aetiology of Kawasaki disease is still unknown but is thought to be related to the combined effects of the immune response, genetic susceptibility, and infections including COVID-19. In this case report, we present a seven months old male infant who presented to us with fever, swollen lips, ulcers in the mouth, enlarged tonsils, strawberry tongue, conjunctivitis and generalised non-blanchable maculopapular rash. The detailed workup fulfilled the criteria of Kawasaki disease. The COVID-19 IgM antibodies were positive. The patient was treated with IV Immunoglobulins, IV methylprednisolone and Aspirin. The repeat echocardiography on six weeks follow-up turned out normal. In conclusion, there should be a high index of suspicion of Kawasaki disease while evaluating pediatric patients with COVID-19 infection so that timely intervention can be made to prevent complications. Prospective studies are needed to evaluate the relationship between Kawasaki Disease and COVID-19 infection.
川崎病是一种全身性血管炎,可影响全身血管。川崎病的病因尚不清楚,但被认为与免疫反应、遗传易感性以及包括新冠病毒感染在内的感染的综合作用有关。在本病例报告中,我们介绍了一名7个月大的男婴,他因发热、嘴唇肿胀、口腔溃疡、扁桃体肿大、草莓舌、结膜炎和全身性非压之褪色的斑丘疹前来就诊。详细检查符合川崎病的标准。新冠病毒IgM抗体呈阳性。该患者接受了静脉注射免疫球蛋白、静脉注射甲泼尼龙和阿司匹林治疗。六周随访时的重复超声心动图检查结果正常。总之,在评估感染新冠病毒的儿科患者时,应高度怀疑川崎病,以便及时进行干预以预防并发症。需要进行前瞻性研究来评估川崎病与新冠病毒感染之间的关系。