Adasooriya Dinuka, Kyeong Minjae, Cho Sung-Won
Division of Anatomy and Developmental Biology, Department of Oral Biology, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.
J Bone Metab. 2023 Feb;30(1):93-101. doi: 10.11005/jbm.2023.30.1.93. Epub 2023 Feb 28.
The skull is a complex structure formed by the craniofacial bones' elaborate organization. The growth pattern in each craniofacial bone of the postnatal skull has been presented in wild-type mice. However, the skull's growth pattern, determined by the craniofacial bones' coordinated growth, is unfamiliar. This study aimed to examine the overall morphological change in the mid-sagittal plane of the postnatal mice's skulls and interaction between the craniofacial bones.
Geometric morphometric principal component analysis was performed in the mid-sagittal plane of 31 wild-type mice's skulls from postnatal days 28 to 98. The relationship between the cranial base and cranial vault was investigated by comparing skulls with early fusion and non-fusion of intersphenoid synchondrosis (ISS).
The cranial vault flattening and sphenoid bone length increased with age. The cranial vault curvature and sphenoid base length showed a positive correlation that was confirmed by comparing the skulls with early fusion and non-fusion of ISS. The sphenoid bone length and cranial vault angle significantly decreased in the skulls with early fusion of ISS compared to non-fusion skulls.
It is suggested that the cranial vault flattening is sphenoid bone length-induced but cranial vault length-independent during postnatal mice skull development.
颅骨是由颅面骨精心组织形成的复杂结构。野生型小鼠已呈现出出生后颅骨各颅面骨的生长模式。然而，由颅面骨协调生长所决定的颅骨生长模式尚不为人所知。本研究旨在研究出生后小鼠颅骨矢状中平面的整体形态变化以及颅面骨之间的相互作用。
对31只出生后28天至98天的野生型小鼠颅骨的矢状中平面进行几何形态测量主成分分析。通过比较蝶骨间软骨结合（ISS）早期融合和未融合的颅骨，研究颅底与颅顶之间的关系。
颅顶变平和蝶骨长度随年龄增加。颅顶曲率和蝶骨基部长度呈正相关，这通过比较ISS早期融合和未融合的颅骨得到证实。与未融合颅骨相比，ISS早期融合的颅骨中蝶骨长度和颅顶角度显著减小。
提示在出生后小鼠颅骨发育过程中，颅顶变平是由蝶骨长度诱导的，而非颅顶长度。
