Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, P. R. China.
Chem Commun (Camb). 2023 Apr 11;59(30):4423-4435. doi: 10.1039/d2cc06212g.
Colorectal cancer is the third most malignant gastrointestinal tumor. Although traditional chemotherapy and radiotherapy have been widely used for treating colorectal cancer, the treatment effect is still unsatisfactory, resulting in a high mortality rate and a low 5-year survival rate. In recent years, with the development of molecular biology of colorectal cancer, many promising therapeutic strategies based on nanomaterials have been developed for colorectal cancer. In this review, we focus on recent advances in colorectal cancer treatment-related nanomedicines. We first discuss the exploration of stimuli-responsive drug delivery systems (DDSs) for colorectal cancer treatment using pH, hypoxia, glutathione (GSH), enzymes, light, magnetic fields (MF), and ultrasound (US) as stimuli. Moreover, the latest progress in emerging therapy for colorectal cancer is further summarized, including photothermal therapy (PTT), magnetothermal therapy (MTT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT). Finally, we explore the existing challenges and future directions for the better design and development of nanomedicines for clinical colorectal cancer treatment.
结直肠癌是第三大恶性胃肠道肿瘤。尽管传统的化疗和放疗已广泛用于治疗结直肠癌，但治疗效果仍不理想，导致死亡率高，5 年生存率低。近年来，随着结直肠癌分子生物学的发展，许多基于纳米材料的有前途的治疗策略已经被开发出来用于结直肠癌的治疗。在这篇综述中，我们重点关注与结直肠癌治疗相关的纳米药物的最新进展。我们首先讨论了利用 pH 值、缺氧、谷胱甘肽 (GSH)、酶、光、磁场 (MF) 和超声 (US) 作为刺激因素，探索用于结直肠癌治疗的响应性药物传递系统 (DDS)。此外，还进一步总结了结直肠癌新兴治疗方法的最新进展，包括光热疗法 (PTT)、磁热疗法 (MTT)、光动力疗法 (PDT)、声动力疗法 (SDT) 和化学动力学疗法 (CDT)。最后，我们探讨了纳米药物更好地设计和开发用于临床结直肠癌治疗的现有挑战和未来方向。
