Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Cancer Med. 2023 May;12(10):11344-11350. doi: 10.1002/cam4.5846. Epub 2023 Mar 23.
Neuroendocrine neoplasm (NEN) of the gallbladder is rare. It is usually asymptomatic and occurs in older adults. Its clinicopathological characteristics remain controversial, and the diagnosis and treatment strategies are usually based on models of adenocarcinoma. The present study aimed to investigate the clinical characteristics and prognosis of gallbladder NEN.
The data of patients with gallbladder NEN admitted to Peking Union Medical College Hospital was reviewed, and a database was established for retrospective analysis. Clinicopathological features were analyzed descriptively and the prognosis was studied according to different factors. The Kaplan-Meier curve was used to describe the cumulative survival rate.
In total, 22 patients with gallbladder NEN were included in this study. There were 10 male (45.5%) and 12 female (54.5%) patients with a median age of onset of NEN at 57.5 (49.0, 62.3) years. Abdominal discomfort was the most common symptom. Twenty patients (90.9%) underwent surgery, and two patients (9.1%) with unresectable lesions underwent a biopsy. Twenty-one patients were followed up. The 1-, 2-, and 3-year cumulative overall survival rates of all patients and patients with resectable lesions were 65.9%, 54.9%, and 48.1%, and 72.9%, 60.7%, and 53.1%, respectively. Patients with resectable lesions had a better cumulative overall survival rate than those who with unresectable lesions (p < 0.001).
Gallbladder NEN is more common in the elderly and has a slight female predominance. The most common symptom is abdominal discomfort. Surgery is the first choice of treatment for this rare disease. The prognosis of gallbladder NEN is generally poor. Patients with resectable lesions have a better prognosis.
胆囊神经内分泌肿瘤（NEN）较为罕见，通常无明显症状，发生于老年人。其临床病理特征仍存在争议，诊断和治疗策略通常基于腺癌模型。本研究旨在探讨胆囊 NEN 的临床特征和预后。
回顾性分析北京协和医院收治的胆囊 NEN 患者的临床资料，建立数据库进行回顾性分析。描述性分析临床病理特征，根据不同因素研究预后。采用 Kaplan-Meier 曲线描述累积生存率。
共纳入 22 例胆囊 NEN 患者，男 10 例（45.5%），女 12 例（54.5%），中位发病年龄为 57.5（49.0，62.3）岁。最常见的症状是腹部不适。20 例（90.9%）患者接受了手术，2 例（9.1%）不可切除病变患者接受了活检。21 例患者获得随访。所有患者和可切除病变患者的 1、2、3 年累积总生存率分别为 65.9%、54.9%和 48.1%和 72.9%、60.7%和 53.1%。可切除病变患者的累积总生存率优于不可切除病变患者（p<0.001）。
胆囊 NEN 多见于老年人，女性略多见。最常见的症状是腹部不适。手术是治疗这种罕见疾病的首选方法。胆囊 NEN 的预后一般较差，可切除病变患者的预后较好。
