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基于 SEER 数据库的胆道神经内分泌肿瘤的临床和预后因素研究。

The clinical and prognostic factors for biliary neuroendocrine neoplasm: a study based on the SEER database.

机构信息

Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Biliary Tract Disease Center, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

出版信息

BMC Surg. 2022 Jun 29;22(1):253. doi: 10.1186/s12893-022-01689-7.

DOI:10.1186/s12893-022-01689-7
PMID:35768809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9245279/
Abstract

BACKGROUND

In this study, we aimed at elucidating the postoperative survival and prognostic factors in patients with biliary neuroendocrine neoplasm (NEN).

METHODS

Cases of biliary system NEN and adenocarcinoma from 1975 to 2016 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. A propensity score matching (PSM) method was used to adjust baseline differences in clinicopathological characteristics in our analysis. The Kaplan-Meier analysis was carried out for survival analysis.

RESULTS

A total of 233 patients with biliary system NEN were enrolled in this study, of which 119 patients' lesions located in gallbladder, while the others' located in bile duct. The postoperative overall survival of bile duct NEN is significantly longer than that of gallbladder NEN (P < 0.001). For gallbladder NENs, surgery method (P = 0.020) and lymph node metastasis (P = 0.018) were identified as independent prognostic factors. In terms of ampulla of vater (AOV) NENs, age (P = 0.017) and lymph node metastasis (P = 0.006) were identified as independent prognostic factors, while grade (P = 0.002) and lymph node metastasis (P = 0.036) were identified as independent prognostic factors for extrahepatic bile duct (EBD) NENs. PSM analysis indicated that patients with biliary duct NENs have a better postoperative prognosis than biliary duct adenocarcinoma.

CONCLUSIONS

Patients with NEN have better overall survival than patients with adenocarcinoma. Gallbladder NEN has an adverse prognosis than that of biliary tract NEN. The pathological subtype, differentiation, lymph node metastasis, surgery method, and lymph node resection could affect the postoperative prognosis of the gallbladder and biliary tract NEN.

摘要

背景

本研究旨在阐明胆道神经内分泌肿瘤（NEN）患者的术后生存和预后因素。

方法

从 1975 年至 2016 年，从监测、流行病学和最终结果（SEER）数据库中提取胆道系统 NEN 和腺癌病例。在我们的分析中，采用倾向评分匹配（PSM）方法来调整临床病理特征的基线差异。进行 Kaplan-Meier 分析进行生存分析。

结果

本研究共纳入 233 例胆道系统 NEN 患者，其中 119 例病变位于胆囊，其余位于胆管。胆管 NEN 的术后总生存率明显长于胆囊 NEN（P < 0.001）。对于胆囊 NEN，手术方法（P = 0.020）和淋巴结转移（P = 0.018）被确定为独立的预后因素。对于壶腹 NEN，年龄（P = 0.017）和淋巴结转移（P = 0.006）被确定为独立的预后因素，而分级（P = 0.002）和淋巴结转移（P = 0.036）被确定为肝外胆管（EBD）NEN 的独立预后因素。PSM 分析表明，胆管 NEN 患者的术后预后优于胆管腺癌患者。

结论

NEN 患者的总体生存率优于腺癌患者。胆囊 NEN 的预后比胆道 NEN 差。病理亚型、分化程度、淋巴结转移、手术方法和淋巴结清扫术可影响胆囊和胆道 NEN 的术后预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/a7007b001cb5/12893_2022_1689_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/24624b29bcdb/12893_2022_1689_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/0b00d2007bf1/12893_2022_1689_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/6646ae68f7c6/12893_2022_1689_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/84fce702d854/12893_2022_1689_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/a7007b001cb5/12893_2022_1689_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/24624b29bcdb/12893_2022_1689_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/0b00d2007bf1/12893_2022_1689_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/6646ae68f7c6/12893_2022_1689_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/84fce702d854/12893_2022_1689_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2799/9245279/a7007b001cb5/12893_2022_1689_Fig5_HTML.jpg

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本文引用的文献

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J Endocrinol Invest. 2022 Apr;45(4):849-857. doi: 10.1007/s40618-021-01715-0. Epub 2022 Jan 18.
2
The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma.胃神经内分泌癌的临床病理特征和总生存分析。
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211055340. doi: 10.1177/15330338211055340.
3
Primary tumor location (right left side of the colon) and resection affect the survival of patients with liver metastases from colonic neuroendocrine carcinoma: a population-based study.
Neuroendocrine Component in Extrahepatic Cholangiocarcinoma is Associated with Better Survival: Data from the SEER Study.
肝外胆管癌中的神经内分泌成分与更好的生存率相关：来自监测、流行病学和最终结果（SEER）研究的数据
Adv Ther. 2023 Sep;40(9):4032-4041. doi: 10.1007/s12325-023-02597-9. Epub 2023 Jul 11.
4
A prognostic nomogram based on log odds of positive lymph nodes to predict the overall survival in biliary neuroendocrine neoplasms (NENs) patients after surgery.一种基于阳性淋巴结对数优势比的预后列线图，用于预测胆管神经内分泌肿瘤（NENs）患者术后的总生存期。
J Endocrinol Invest. 2022 Dec;45(12):2341-2351. doi: 10.1007/s40618-022-01874-8. Epub 2022 Jul 30.
原发性肿瘤位置（结肠右侧或左侧）及切除术对结肠神经内分泌癌肝转移患者生存的影响：一项基于人群的研究
Therap Adv Gastroenterol. 2021 Oct 29;14:17562848211036453. doi: 10.1177/17562848211036453. eCollection 2021.
4
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.美国胃肠胰神经内分泌肿瘤患者总体生存的流行病学趋势及相关因素。
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5
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6
Risk of preoperative understaging of duodenal neuroendocrine neoplasms: a plea for caution in the treatment strategy.十二指肠神经内分泌肿瘤术前分期不足的风险：治疗策略需谨慎。
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