Yamate J, Tajima M, Maruyama Y, Kudow S
Nippon Institute for Biological Science, Tokyo, Japan.
Lab Anim. 1987 Oct;21(4):289-98. doi: 10.1258/002367787781363309.
Male and female DBA/2NCrj (DBA/2) mice 3, 4, 5 and 10 weeks old were examined biochemically and pathologically and the results obtained were compared with those for CRJ:CD-1 (ICR) mice of the same age. The plasma levels of glucose, triglyceride and total cholesterol tended to be lower in DBA/2 mice than in ICR mice but the levels of non-esterified fatty acid, calcium and inorganic phosphorus were almost the same in the two strains. The mean body weight of DBA/2 mice was significantly lower than that of ICR mice at each examination, and the relative weights of the hearts of male and female DBA/2 mice were significantly greater than those of male and female ICR mice. Cardiac calcinosis, tongue calcification and corneal degeneration occurred exclusively in DBA/2 mice with incidences of 30%-100%. The incidence and severity of these lesions increased with age but no sex differences were seen. It was difficult to relate differences in biochemical features of the two strains with pathological findings obtained in the DBA/2 mice. The numbers of cells secreting adrenocorticotropic hormone in the pituitary glands were significantly greater in male and female DBA/2 mice than in ICR mice, suggesting a higher secretion of corticosteroids in the former strain.
对3周、4周、5周和10周龄的雄性和雌性DBA/2NCrj（DBA/2）小鼠进行了生化和病理检查，并将所得结果与相同年龄的CRJ:CD-1（ICR）小鼠的结果进行了比较。DBA/2小鼠的血浆葡萄糖、甘油三酯和总胆固醇水平往往低于ICR小鼠，但两品系的非酯化脂肪酸、钙和无机磷水平几乎相同。每次检查时，DBA/2小鼠的平均体重均显著低于ICR小鼠，并且雄性和雌性DBA/2小鼠心脏的相对重量均显著大于雄性和雌性ICR小鼠。心脏钙化、舌钙化和角膜变性仅发生在DBA/2小鼠中，发生率为30%-100%。这些病变的发生率和严重程度随年龄增加而增加，但未见性别差异。很难将两品系的生化特征差异与DBA/2小鼠的病理结果联系起来。雄性和雌性DBA/2小鼠垂体中分泌促肾上腺皮质激素的细胞数量显著多于ICR小鼠，提示前一品系中皮质类固醇的分泌较高。
