Maeda N, Doi K, Mitsuoka T
Lab Anim. 1986 Jan;20(1):5-8. doi: 10.1258/002367786781062151.
The development of heart and aortic lesions was investigated in 3- to 8-week-old DBA/2NCrj mice. In the heart, small foci of myocardial calcification and severe calcification with subsequent inflammation were observed. Severe lesions were restricted to the myocardium below the right ventricular epicardium. Small foci of myocardial calcification were found from 4 to 8 weeks of age with almost the same frequency. The incidence of severe calcification showed a drastic increase between 6 and 7 weeks of age. Aortic lesions were observed from 3 weeks of age and characterized by focal calcification of the smooth muscle cells and elastic laminae. The frequency of aortic calcification was about 50% and not age-related.
对3至8周龄的DBA/2NCrj小鼠的心脏和主动脉病变发展情况进行了研究。在心脏中，观察到心肌钙化的小病灶以及随后伴有炎症的严重钙化。严重病变局限于右心室心外膜下方的心肌。在4至8周龄时发现心肌钙化小病灶的频率几乎相同。严重钙化的发生率在6至7周龄之间急剧上升。主动脉病变在3周龄时即可观察到，其特征为平滑肌细胞和弹性层的局灶性钙化。主动脉钙化的频率约为50%，与年龄无关。
