患有钙化舌病变的DBA/2NCrj和CBA/BrA小鼠血清中碱性磷酸酶的活性。

The activity of alkaline phosphatase in the sera of DBA/2NCrj and CBA/BrA mice with calcified tongue lesions.

作者信息

Matsushima Y, Ikeno T

机构信息

Department of Laboratory Animal Science, Tohoku Dental University, Fukushima, Japan.

出版信息

Jikken Dobutsu. 1987 Oct;36(4):395-8. doi: 10.1538/expanim1978.36.4_395.

DOI:10.1538/expanim1978.36.4_395

PMID:3436372

Abstract

Spontaneously occurring calcified lesions were found in the tongues of DBA/2NCrj and CBA/BrA mice. In the DBA/2NCrj strain, the frequency of the lesion was 80% (males) and 88% (females). The youngest age of a mouse with this lesion was 18 days after birth, and 3-4 lesions were found in the tongue of 6- to 8-week-old mice. In CBA/BrA mice, 20% of females and 48% of males had the lesions. No significant differences were found in the serum calcium concentrations in high and low lesion-developing strains, but the alkaline phosphatase activities in the high-developing DBA/2NCrj, DBA/LiA, and CBA/BrA strains were higher than in strains with no calcified lesions.

摘要

在DBA/2NCrj和CBA/BrA小鼠的舌头中发现了自发形成的钙化病变。在DBA/2NCrj品系中，病变的发生率在雄性小鼠中为80%，在雌性小鼠中为88%。出现这种病变的小鼠最小年龄为出生后18天，在6至8周龄小鼠的舌头中发现3至4个病变。在CBA/BrA小鼠中，20%的雌性和48%的雄性有病变。在高病变发生率品系和低病变发生率品系中，血清钙浓度未发现显著差异，但高病变发生率的DBA/2NCrj、DBA/LiA和CBA/BrA品系中的碱性磷酸酶活性高于无钙化病变的品系。