炔诺酮避孕微球

Norethisterone contraceptive microspheres.

作者信息

Rivera R, Alvarado G, Flores C, Aldaba S, Hernandez A

机构信息

Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Avenida Universidad, Durango, Mexico.

出版信息

J Steroid Biochem. 1987;27(4-6):1003-7. doi: 10.1016/0022-4731(87)90181-6.

DOI:10.1016/0022-4731(87)90181-6

PMID:3695501

Abstract

Two formulations of polylactic and polyglycolic acid microcapsules containing 75 and 100 mg of NET respectively were studied for a 90-day period of anticipated contraceptive effect in two groups of five women. A 200 mg dose of NET preparation was also studied for a 180-day period of anticipated contraceptive effect in 19 women. Alteration in menstrual cycle, with tendency to short bleeding episodes, spotting days, and amenorrhea were the most important collateral effects. In the majority of cases, ovulation was inhibited. No cases of pregnancy were presented. The obtained NET circulating levels were very stable during the period of anticipated contraceptive effect.

摘要

研究了分别含有75毫克和100毫克炔诺酮的两种聚乳酸-乙醇酸微胶囊制剂，在两组各五名女性中进行了为期90天的预期避孕效果研究。还对19名女性研究了200毫克剂量的炔诺酮制剂，为期180天的预期避孕效果。月经周期改变，伴有出血时间缩短、点滴出血天数和闭经倾向是最重要的副作用。在大多数情况下，排卵受到抑制。未出现怀孕病例。在预期避孕效果期间，所获得的炔诺酮循环水平非常稳定。