Song S, Chen J K, Lu C H, Yang P J, Yang Q Y, Fan B C, He M L, Gui Y L, Li L M, Fotherby K
Institute of Planned Parenthood Research, Shanghai, China.
Contraception. 1993 Jun;47(6):527-37. doi: 10.1016/0010-7824(93)90021-x.
The ovarian effects of different doses of norethisterone (NET) were compared in 45 normally menstruating women in order to find the lowest effective dose of the Chinese NET "visiting pill". Subjects were randomly divided into 3 groups. Each subject in each group was taking 0.5, 1.5 or 3.0 mg per day from days 5 to day 18 of the cycle. Blood samples were taken on days 5, 8, 11, 14, 17, 20, 23, 26 and 29 of the cycle. Serum oestradiol (E2), progesterone (P), sex hormone binding globulin (SHBG), high density-lipoprotein cholesterol (HDL-C), and NET concentrations were measured. Ovulation, delayed ovulation, ovulation inhibition and follicular activity were classified by the analysis of the peripheral serum levels of sex hormones. Ovulation occurred in 7 women in the 0.5 mg group, in 2 women in the 1.5 mg group and in none of the 3.0 mg group. Mean serum SHBG levels were reduced progressively by 6.6% (Group 0.5), 15.5% (Group 1.5) and 23.4% (Group 3.0). There were no significant changes in HDL-C levels in any group. There was a significant correlation of mean serum NET concentrations with dose. The lack of complete inhibition of ovulation in most women in the 1.5 mg and 0.5 mg groups might suggest that the dose of NET required when used as a visiting pill could not be reduced below 3.0 mg.
为了找到中国炔诺酮“探亲片”的最低有效剂量，对45名月经正常的女性进行了不同剂量炔诺酮（NET）的卵巢效应比较。受试者被随机分为3组。每组中的每个受试者在月经周期的第5天至第18天每天服用0.5、1.5或3.0毫克。在月经周期的第5、8、11、14、17、20、23、26和29天采集血样。测定血清雌二醇（E2）、孕酮（P）、性激素结合球蛋白（SHBG）、高密度脂蛋白胆固醇（HDL-C）和NET浓度。通过分析外周血清性激素水平对排卵、排卵延迟、排卵抑制和卵泡活性进行分类。0.5毫克组有7名女性排卵，1.5毫克组有2名女性排卵，3.0毫克组无女性排卵。平均血清SHBG水平分别逐渐降低6.6%（0.5毫克组）、15.5%（1.5毫克组）和23.4%（3.0毫克组）。任何组的HDL-C水平均无显著变化。平均血清NET浓度与剂量之间存在显著相关性。1.5毫克组和0.5毫克组的大多数女性未完全抑制排卵可能表明，炔诺酮作为探亲片使用时所需的剂量不能降低到3.0毫克以下。
