Swoboda H, Braun P, Schratter M
1. Hals-Nasen-Ohrenklinik der Universität Wien.
Laryngol Rhinol Otol (Stuttg). 1987 Oct;66(10):557-61.
A case of early onset type of juvenile laryngeal papillomatosis (JLP) is reported, where pulmonary involvement developed in typical aspiration site evidenced by tuberculosis of the right lung, and which stimulated after years a squamous epithelial carcinoma. After comparison of this case with similar cases reported in the literature, the clinical feature of cancerization in JLP is discussed in the context of recent virological, immunohistochemical and pathohistological findings. The infectious nature of this disease and the reparative character of the pathologically accelerated proliferation of the papilloma epithelium are stressed, which latter is thus particularly susceptible to additional noxae: irradiation, cigarette smoke, infection and necrosis. These noxae are considered to be the ultimate cause of cancerization in JLP, especially long-standing necrosis. These noxae are considered to be the ultimate cause of cancerization in JLP, especially long-standing necrotisation of lung structures in pulmonary involvement. Surgical treatment of JLP, eradication being unconceivable, should therefore be rather conservative, and any therapeutic attendance should take utmost care to avoid intrapulmonary seeding.
报告了一例早发型青少年喉乳头状瘤病（JLP），其肺部受累发生在典型的吸入部位，右肺结核可证实，多年后引发了鳞状上皮癌。将该病例与文献中报道的类似病例进行比较后，结合近期病毒学、免疫组织化学和病理组织学研究结果，讨论了JLP癌变的临床特征。强调了该疾病的传染性以及乳头状瘤上皮病理加速增殖的修复特性，因此后者特别易受其他有害因素影响：辐射、香烟烟雾、感染和坏死。这些有害因素被认为是JLP癌变的最终原因，尤其是长期坏死。这些有害因素被认为是JLP癌变的最终原因，尤其是肺部受累时肺结构的长期坏死。JLP的手术治疗无法彻底根除，因此应较为保守，任何治疗都应格外小心，避免肺内播散。
