Schnadig V J, Clark W D, Clegg T J, Yao C S
Arch Otolaryngol Head Neck Surg. 1986 Sep;112(9):966-71. doi: 10.1001/archotol.1986.03780090062011.
Juvenile laryngeal papillomatosis (JLP), usually a benign, self-limited disease, occasionally has a highly aggressive course characterized by extension of neoplastic cells into the tracheobronchial tree, lung, and soft tissues. Less frequently, squamous carcinoma has arisen in JLP, most commonly following radiation therapy. Rarely, carcinoma has occurred without previous irradiation, but distant metastases do not generally occur. We describe a 14-year-old boy, with a particularly aggressive form of JLP, who developed invasion of the lungs, intrapulmonary lymph nodes, and arteries by cytologically benign neoplastic tissue. He also developed a metastasizing squamous carcinoma of the lung and humoral hypercalcemia of malignancy. A discussion of the implications of the case and a review of the current literature are provided.
青少年喉乳头状瘤病（JLP）通常是一种良性的自限性疾病，但偶尔也会呈现高度侵袭性病程，其特征为肿瘤细胞扩展至气管支气管树、肺和软组织。较少见的情况是，JLP会发生鳞状细胞癌，最常见于放射治疗之后。极少有在未接受过放疗的情况下发生癌变的，但一般不会发生远处转移。我们报告一名14岁男孩，患有一种特别侵袭性的JLP，其细胞学上为良性的肿瘤组织侵犯了肺、肺内淋巴结和动脉。他还发生了肺转移性鳞状细胞癌和恶性肿瘤所致的体液性高钙血症。本文对该病例的意义进行了讨论，并对当前文献进行了综述。
