肠道微生物组与胰腺癌的发生发展和治疗。
The Gut Microbiome and Pancreatic Cancer Development and Treatment.
机构信息
From the Cancer Biology Graduate Program.
出版信息
Cancer J. 2023;29(2):49-56. doi: 10.1097/PPO.0000000000000647.
Abstract
Changes in the gut microbiome have been increasingly shown to accompany oncogenesis across various tumors. Similarly, microbial dysbiosis was found to be associated with pancreatic cancer progression and survival outcomes, expanding the field of tumor microenvironment research in pancreatic cancer. Mechanistic studies in pancreatic cancer models implicate components of the gut and pancreatic cancer microbiome in regulating tumorigenesis by altering cancer cell signaling, modulating immune function, and influencing the efficacy of current therapies in pancreatic cancer. This review discusses the outcomes of microbial modulation across various preclinical and clinical studies and highlights ongoing trials targeting the microbiome for pancreatic cancer therapy.
摘要
肠道微生物组的变化已被越来越多地证明与各种肿瘤的发生有关。同样，微生物失调也被发现与胰腺癌的进展和生存结果有关，这拓展了胰腺癌肿瘤微环境研究的领域。在胰腺癌模型中的机制研究表明，肠道和胰腺癌微生物组的成分通过改变癌细胞信号、调节免疫功能以及影响当前胰腺癌治疗的疗效，来调节肿瘤发生。本综述讨论了各种临床前和临床研究中微生物调节的结果，并强调了针对胰腺癌治疗的微生物组的正在进行的试验。
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