Kawai K, Fujibayashi Y, Yonekura Y, Tanaka K, Saji H, Konishi J, Kubodera A, Yokoyama A
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Ann Nucl Med. 1995 Feb;9(1):47-50. doi: 10.1007/BF03165009.
We have already reported that 123I-3-iodo-alpha-methyl-L-tyrosine (123I-L-AMT) is superior as a single-photon emitter labeled radiopharmaceutical reflecting cerebral amino acid transport. In this study, we investigated the distribution of 123I-L-AMT in the canine head by means of SPECT and kinetically analyzed the data in the brain. As a result, clear SPECT images of the canine brain were obtained. Kinetic analysis with a 2-compartment model, including or expressing membrane transport of the amino acid, was performed with time-activity curves in the arterial blood and in the cerebral region. The results of the analysis coincided closely with the experimental data and the relevance of the model was strongly suggested. Therefore 123I-L-AMT is considered to be useful as a single photon radiopharmaceutical which enables us to measure the cerebral amino acid transport rate.
我们已经报道过，123I-3-碘-α-甲基-L-酪氨酸（123I-L-AMT）作为反映脑氨基酸转运的单光子发射体标记放射性药物具有优越性。在本研究中，我们通过SPECT研究了123I-L-AMT在犬头部的分布，并对脑部数据进行了动力学分析。结果，获得了清晰的犬脑SPECT图像。采用包括或表达氨基酸膜转运的二室模型，根据动脉血和脑区的时间-活性曲线进行动力学分析。分析结果与实验数据密切吻合，强烈提示该模型的相关性。因此，123I-L-AMT被认为是一种有用的单光子放射性药物，能够使我们测量脑氨基酸转运速率。
