Children's Healthcare of Atlanta, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Nihon Kohden, Irvine, CA, USA.
Epilepsy Res. 2023 May;192:107129. doi: 10.1016/j.eplepsyres.2023.107129. Epub 2023 Mar 21.
Presurgical evaluation of refractory epilepsy involves functional investigations to minimize postoperative deficit. Assessing language and memory is conventionally undertaken using Wada and fMRI, and occasionally supplemented by data from invasive intracranial electroencephalography, such as electrical stimulation, corticortical evoked potentials, mapping of high frequency activity and phase amplitude coupling. We describe the comparative and complementary role of these methods to inform surgical decision-making and functional prognostication. We used Wada paradigm to standardize testing across all modalities. Postoperative neuropsychological testing confirmed deficit predicted based on these methods.
术前评估难治性癫痫需要进行功能研究以最大程度地减少术后缺陷。传统上,使用 Wada 测试和 fMRI 评估语言和记忆,偶尔还会补充来自侵袭性颅内脑电图的数据,例如电刺激、皮质诱发电位、高频活动和相位振幅耦合的映射。我们描述了这些方法的比较和互补作用,以告知手术决策和功能预后。我们使用 Wada 范式使所有模式的测试标准化。术后神经心理学测试证实了这些方法预测的缺陷。
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