George Derek D, Ojemann Steven G, Drees Cornelia, Thompson John A
School of Medicine, University of Colorado School of Medicine, Aurora, CO, United States.
Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, United States.
Front Neurol. 2020 May 12;11:320. doi: 10.3389/fneur.2020.00320. eCollection 2020.
Electrical stimulation mapping (ESM) using stereoelectroencephalography (SEEG) is an essential component in the workup of surgical epilepsy. Since the initial application of ESM in the mid-1960s, it remains unparalleled in defining eloquent brain areas and delimiting seizure foci for the purposes of surgical planning. Here, we briefly review the current state of SEEG stimulation, with a focus on the techniques used for identifying the epileptogenic zone and eloquent cortex. We also summarize clinical data on the efficacy of SEEG stimulation in surgical outcomes and functional mapping. Finally, we briefly highlight future applications of SEEG ESM, including novel functional mapping approaches, identifying rare seizure semiologies, neurophysiologic investigations for understanding cognitive function, and its role in SEEG-guided radiofrequency thermal coagulation.
使用立体定向脑电图（SEEG）的电刺激图谱（ESM）是外科癫痫检查的重要组成部分。自20世纪60年代中期ESM首次应用以来，在为手术规划确定明确的脑区和划定癫痫病灶方面，它仍然是无与伦比的。在此，我们简要回顾SEEG刺激的现状，重点关注用于识别致痫区和明确皮质的技术。我们还总结了关于SEEG刺激在手术结果和功能图谱方面疗效的临床数据。最后，我们简要强调SEEG ESM的未来应用，包括新型功能图谱方法、识别罕见癫痫发作症状、用于理解认知功能的神经生理学研究，以及其在SEEG引导下的射频热凝中的作用。
