Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Diabetes Res Clin Pract. 2023 May;199:110604. doi: 10.1016/j.diabres.2023.110604. Epub 2023 Mar 22.
This systematic review and meta-analysis sought to evaluate the effects ofguar gum supplementation on glycemic control, blood pressure, and body mass in adults.
Relevant studies were obtained by searching the PubMed, SCOPUS, Embase, and Web of Science databases (from inception to January 2022). Weighted mean differences (WMD) and 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods.
Pooled analysis of 14 randomized controlled trials (RCTs) revealed that guar gum supplementation led to significant reductions in hemoglobin A1c (HbA1c) (WMD: -0.47 mg/dL, 95% CI: -0.75, -0.18, p = 0.001). However, there was no effect on fasting blood sugar (FBS), systolic and diastolic blood pressure, and body mass among adults in comparison with the control group. A subgroup analysis demonstrated that intervention in patients with type 2 diabetes (T2DM), and high supplementation dosages (>15 g/d) significantly decreased FBS concentrations, but not in other subgroups.
Guar gum supplementation may yield a beneficial effect on glycemic control in T2DM patients. However, the extant clinical trials, thus far, are not sufficient enough to form guidelines for clinical practice.
本系统评价和荟萃分析旨在评估瓜尔胶补充剂对成年人血糖控制、血压和体重的影响。
通过检索 PubMed、SCOPUS、Embase 和 Web of Science 数据库（从成立到 2022 年 1 月）获取相关研究。使用随机效应模型汇总加权均数差（WMD）和 95%置信区间（CI）。采用标准方法报告异质性、敏感性分析和发表偏倚。
对 14 项随机对照试验（RCT）的汇总分析表明，瓜尔胶补充剂可显著降低血红蛋白 A1c（HbA1c）（WMD：-0.47mg/dL，95%CI：-0.75，-0.18，p=0.001）。然而，与对照组相比，瓜尔胶补充剂对成年人的空腹血糖（FBS）、收缩压和舒张压以及体重没有影响。亚组分析表明，在 2 型糖尿病（T2DM）患者和高补充剂量（>15g/d）的干预下，FBS 浓度显著降低，但在其他亚组中没有。
瓜尔胶补充剂可能对 T2DM 患者的血糖控制有有益的影响。然而，迄今为止，现有的临床试验还不足以制定临床实践指南。
