对盲肠内注射抗原性小鼠肿瘤细胞的血清学反应。
Serological response to intracaecal injections of antigenic mouse tumour cells.
作者信息
Laursen M L
出版信息
Br J Cancer. 1978 Dec;38(6):692-8. doi: 10.1038/bjc.1978.274.
Abstract
Immunofluorescence studies of sera from mice with induced enhancement of tumour growth demonstrated that these sera contained factors ("interfering factors") which in an apparently competitive manner interfered with the subsequent binding of specific antibodies to antigenic sites on the tumour-cell membrane. The factors were tumour-specific but lacked some of the immunoglobulin determinants. They could not be detected by polyvalent FITC-antimouse gamma-globulin. Interfering factors did not seem to be related to IgA or IgE. They were demonstrable in sera from tumour-free animals without growing tumours, thus differing from the tumour-specific "blocking factors".
摘要
对肿瘤生长诱导增强的小鼠血清进行免疫荧光研究表明，这些血清含有一些因子（“干扰因子”），这些因子以明显竞争性的方式干扰随后特异性抗体与肿瘤细胞膜上抗原位点的结合。这些因子具有肿瘤特异性，但缺乏一些免疫球蛋白决定簇。用多价异硫氰酸荧光素抗小鼠γ球蛋白无法检测到它们。干扰因子似乎与IgA或IgE无关。在无肿瘤动物的血清中也能检测到这些因子，这些动物并没有正在生长的肿瘤，因此与肿瘤特异性“封闭因子”不同。
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