通过盲肠内途径免疫增强两种同基因C3H小鼠系统中的肿瘤生长。
Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
作者信息
Laursen M L, Laursen K
出版信息
Br J Cancer. 1978 Jun;37(6):1039-45. doi: 10.1038/bjc.1978.151.
Over the past 70 years many experiments have been designed to promote tumour growth. These studies were all carried out in allogeneic tumour systems or by artificially influencing the immunization process. In the present study, the growth of syngeneic mammary tumour cells was enhanced by prior immunization via the intracaecal route. Such induced enhancement could be transferred to untreated animals by serum or by spleen cells. Tumour growth was also enhanced in another syngeneic system by immunization via the intestinal route with frozen-thawed ascites tumour cells. The result is in direct contrast to that obtained by similar immunization with live cells, which affords protection against a later challenge.
在过去70年里，人们设计了许多实验来促进肿瘤生长。这些研究均在同种异体肿瘤系统中进行，或通过人为影响免疫过程来开展。在本研究中，通过盲肠内途径预先免疫可增强同基因乳腺肿瘤细胞的生长。这种诱导增强作用可通过血清或脾细胞传递给未处理的动物。在另一个同基因系统中，通过用冻融腹水肿瘤细胞经肠道途径免疫也可增强肿瘤生长。这一结果与用活细胞进行类似免疫所获得的结果直接相反，后者可提供针对后续攻击的保护作用。
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