环磷酰胺作为一种抗肿瘤药物会适得其反吗？
Is cyclophosphamide self-defeating as an antitumor agents?
作者信息
Laursen M L
出版信息
J Cancer Res Clin Oncol. 1980;97(1):87-90. doi: 10.1007/BF00411282.
Abstract
The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor cells. The possibility that the antigenicity of tumor cells might be an important factor in obtaining successful therapy with CPA is proposed.
摘要
该研究表明，环磷酰胺（CPA）对通过胃内接种肿瘤预先免疫的小鼠体内生长的乳腺癌的抗肿瘤作用受到抑制。通过这种途径用肿瘤细胞进行免疫在某些条件下会产生能够调节肿瘤细胞上抗原决定簇的因子。有人提出肿瘤细胞的抗原性可能是用CPA获得成功治疗的一个重要因素。
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本文引用的文献
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Immunological enhancement induced by gastrointestinal immunization of mice pretreated with cyclophosphamide.环磷酰胺预处理小鼠经胃肠道免疫诱导的免疫增强作用。
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