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环磷酰胺作为一种抗肿瘤药物会适得其反吗？

Is cyclophosphamide self-defeating as an antitumor agents?

作者信息

Laursen M L

出版信息

J Cancer Res Clin Oncol. 1980;97(1):87-90. doi: 10.1007/BF00411282.

DOI:10.1007/BF00411282
PMID:7400210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253885/
Abstract

The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor cells. The possibility that the antigenicity of tumor cells might be an important factor in obtaining successful therapy with CPA is proposed.

摘要

该研究表明，环磷酰胺（CPA）对通过胃内接种肿瘤预先免疫的小鼠体内生长的乳腺癌的抗肿瘤作用受到抑制。通过这种途径用肿瘤细胞进行免疫在某些条件下会产生能够调节肿瘤细胞上抗原决定簇的因子。有人提出肿瘤细胞的抗原性可能是用CPA获得成功治疗的一个重要因素。

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本文引用的文献

1
Immunological enhancement induced by gastrointestinal immunization of mice pretreated with cyclophosphamide.环磷酰胺预处理小鼠经胃肠道免疫诱导的免疫增强作用。
J Cancer Res Clin Oncol. 1980;96(3):231-41. doi: 10.1007/BF00408096.
2
The influence of host factors on cyclophosphamide treatment of Moloney virus-induced lymphomas.宿主因素对环磷酰胺治疗莫洛尼病毒诱导的淋巴瘤的影响。
Eur J Cancer (1965). 1970 Aug;6(4):277-86. doi: 10.1016/0014-2964(70)90091-5.
3
Suppression by cytosine arabinoside of serum-blocking factors of cell-mediated immunity to syngeneic transplants of mouse mammary tumors.阿糖胞苷对小鼠乳腺肿瘤同基因移植细胞介导免疫血清阻断因子的抑制作用。
J Natl Cancer Inst. 1972 Apr;48(4):1161-7.
4
Effect of cyclophosphamide on syngeneic transplantation of para-adenovirus-7-transformed tumor cells in hamsters.环磷酰胺对仓鼠中腺病毒-7转化肿瘤细胞同基因移植的影响。
Int J Cancer. 1972 May 15;9(3):659-65. doi: 10.1002/ijc.2910090324.
5
Selective suppression of humoral and cellular immunity with cytosine arabinoside.用阿糖胞苷选择性抑制体液免疫和细胞免疫。
Cancer Res. 1972 Feb;32(2):298-301.
6
Disappearance after chemotherapy of blocking serum factors as measured in vitro with lymphocytes cytotoxic to tumor cells.化疗后，用对肿瘤细胞具有细胞毒性的淋巴细胞在体外检测时，阻断血清因子消失。
Cancer. 1972 Dec;30(6):1428-37. doi: 10.1002/1097-0142(197212)30:6<1428::aid-cncr2820300603>3.0.co;2-h.
7
The effects of cyclophosphamide on in vitro correlates of tumor immunity.环磷酰胺对肿瘤免疫体外相关指标的影响。
Int J Cancer. 1974 Dec 15;14(6):743-52. doi: 10.1002/ijc.2910140608.
8
Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.通过盲肠内途径免疫增强两种同基因C3H小鼠系统中的肿瘤生长。
Br J Cancer. 1978 Jun;37(6):1039-45. doi: 10.1038/bjc.1978.151.
9
Serological response to intracaecal injections of antigenic mouse tumour cells.对盲肠内注射抗原性小鼠肿瘤细胞的血清学反应。
Br J Cancer. 1978 Dec;38(6):692-8. doi: 10.1038/bjc.1978.274.