FOXM1：一个制造更多癌症进展和转移轨迹的小狐狸。
FOXM1: A small fox that makes more tracks for cancer progression and metastasis.
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
出版信息
Semin Cancer Biol. 2023 Jul;92:1-15. doi: 10.1016/j.semcancer.2023.03.007. Epub 2023 Mar 22.
Abstract
Transcription factors (TFs) are indispensable for the modulation of various signaling pathways associated with normal cell homeostasis and disease conditions. Among cancer-related TFs, FOXM1 is a critical molecule that regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features. FOXM1 also impact the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors (ICIs) in various cancer types. Recent advances in cancer research strengthen the cancer-specific role of FOXM1, providing a rationale to target FOXM1 for developing targeted therapies. This review compiles the recent studies describing the pivotal role of FOXM1 in promoting metastasis of various cancer types. It also implicates the contribution of FOXM1 in the modulation of chemotherapeutic resistance, antitumor immune response/immunotherapies, and the potential of small molecule inhibitors of FOXM1.
摘要
转录因子（TFs）对于调节与正常细胞内稳态和疾病状况相关的各种信号通路是不可或缺的。在与癌症相关的 TFs 中，FOXM1 是一个关键分子，它调节癌细胞的多个方面，包括生长、转移、复发和干细胞特征。FOXM1 还影响各种癌症类型的靶向治疗、化疗和免疫检查点抑制剂（ICIs）的疗效。癌症研究的最新进展加强了 FOXM1 的癌症特异性作用，为开发针对 FOXM1 的靶向治疗提供了依据。这篇综述汇集了最近描述 FOXM1 在促进各种癌症类型转移中关键作用的研究。它还暗示了 FOXM1 在调节化疗耐药性、抗肿瘤免疫反应/免疫疗法以及 FOXM1 的小分子抑制剂的潜力方面的作用。
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