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一例曲折多变的慢性髓系白血病有趣病例。

An interesting case of chronic myeloid leukemia with twists and turns.

作者信息

Ramalingam Thulasi Raman, Subramanian J, Nagarathinam I, Chandran C, Vaidhyanathan L, Easow J M

机构信息

Apollo Cancer Centre, Chennai, India.

Apollo Cancer Centre, Chennai, India.

出版信息

Hematol Transfus Cell Ther. 2024 Dec;46 Suppl 6(Suppl 6):S385-S388. doi: 10.1016/j.htct.2023.02.001. Epub 2023 Mar 7.

DOI:10.1016/j.htct.2023.02.001
PMID:36958954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11726053/
Abstract

Additional cytogenetic abnormalities (ACA) are known to crop up in Ph cells of chronic myeloid leukemia (CML) patients due to cytogenetic evolution. But the frequency of molecular evolution and ACA is much less in Ph cells of CML patients and is poorly understood. We report an interesting and rare case of Ph CML, who progressed to B lymphoblastic crisis, achieved remission, and later developed Ph acute myeloid leukemia (AML) with KMT2A gene rearrangement and no detectable BCR- ABL transcripts.

摘要

已知由于细胞遗传学进化，慢性髓性白血病（CML）患者的Ph细胞中会出现额外的细胞遗传学异常（ACA）。但CML患者Ph细胞中的分子进化和ACA频率要低得多，对此了解甚少。我们报告了一例有趣且罕见的Ph CML病例，该患者进展为B淋巴细胞危象，实现缓解，后来发展为具有KMT2A基因重排且未检测到BCR-ABL转录本的Ph急性髓性白血病（AML）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/3137c941a984/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/1cfe926d2e61/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/feea826ff9db/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/3137c941a984/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/1cfe926d2e61/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/feea826ff9db/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b0f/11726053/3137c941a984/gr3.jpg

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