School of Medicine, Stanford University, Stanford, California, USA.
Department of Nanoscience, Brown University, Providence, Rhode Island, USA.
Curr Cardiol Rev. 2023;19(5):19-26. doi: 10.2174/1573403X19666230320165821.
HFpEF is one of the leading causes of death whose burden is estimated to expand in the coming decades. This paper examines the relationship between circulating levels of galectin-3, an emerging risk factor for cardiovascular disease, and the clinical diagnosis of HFpEF.
The authors reviewed peer-reviewed literature and 18 studies met the inclusion criteria. Study characteristics, study outcome definitions, assay characteristics, main findings, and measures of association were tabulated and summarized.
Five studies found significant associations between galectin-3 and HFpEF diagnosis compared to healthy controls, and one did not. Five studies found significant associations between galectin- 3 concentration in circulation and severity of diastolic dysfunction. Three studies found a statistically significant association between circulating galectin-3 and all-cause mortality or rehospitalization. Two studies found levels of circulating galectin-3 to be a statistically significant predictor of later HFpEF onset. Finally, two studies examined whether galectin-3 was associated with incident HFpEF, one found a significant association and the other did not.
Given the paucity of effective therapeutics for HFpEF, galectin-3 shows promise as a possible HFpEF-linked biomarker that may, with further study, inform and predict treatment course to reduce morbidity and mortality.
HFpEF 是导致死亡的主要原因之一，其负担预计在未来几十年内会增加。本文研究了循环中半乳糖凝集素-3（一种新兴的心血管疾病风险因素）的水平与 HFpEF 的临床诊断之间的关系。
作者回顾了同行评议的文献，并纳入了 18 项符合条件的研究。列出并总结了研究特征、研究结果定义、检测特征、主要发现和关联测量。
五项研究发现，与健康对照组相比，半乳糖凝集素-3与 HFpEF 诊断之间存在显著关联，一项研究未发现显著关联。五项研究发现，循环中半乳糖凝集素-3浓度与舒张功能障碍的严重程度之间存在显著关联。三项研究发现，循环中半乳糖凝集素-3与全因死亡率或再住院率之间存在统计学显著关联。两项研究发现，循环中半乳糖凝集素-3水平是 HFpEF 后期发病的统计学显著预测因素。最后，两项研究检查了半乳糖凝集素-3是否与 HFpEF 发病有关，一项研究发现存在显著关联，另一项研究则未发现。
鉴于 HFpEF 的有效治疗方法有限，半乳糖凝集素-3作为一种可能的 HFpEF 相关生物标志物具有一定的前景，进一步的研究可能会为治疗方案提供信息并进行预测，以降低发病率和死亡率。
