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中东和北非地区药学研究人员对利益冲突的认识与认知:一项研究

Awareness and perception of pharmacy researchers about conflict of interest: A study from the MENA region.

作者信息

Mashaqhbeh Hadeia, Alzoubi Karem H, Khabour Omar F, Abu-Farha Rana

机构信息

Department of Pharmaceutical Technology, Jordan University of Science and Technology, Irbid 22110, Jordan.

Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, UAE.

出版信息

J Appl Pharm Sci. 2022 Aug;12(8):148-155. doi: 10.7324/japs.2022.120815. Epub 2022 Aug 4.

Abstract

The literature has shown some bias in research about the effectiveness and efficacy of medications due to the influence of the pharmaceutical industry. Thus, researchers' understanding of conflict of interest (COI) is substantial and may influence the quality of scientific research. Therefore, in this study, we aimed to assess pharmacy researchers' awareness and perception about COI in the Middle East and North Africa (MENA) region and the factors affecting their disclosure of COI. In this cross-sectional study, a convenience sample of pharmacy researchers from the MENA region was surveyed for their awareness and perception about the principles of COI. The questionnaire was divided into three main sections. The first section assesses the demographic information of the study participants; the second section assesses researchers' awareness and practices in dealing with COI; and, finally, the third section assesses participants' perception about COI. The questionnaire was uploaded on the Google Forms electronic platform, and it was distributed to the potential study participants via their professional emails. Finally, logistic analysis was used to evaluate predictors affecting COI disclosure by the study participants. A total of 271 pharmacy researchers participated in this study. Researchers were distributed based on their academic rank as follows: 63 professors (23.3%), 59 associate professors (21.8%), 97 assistant professors (35.8%), and 52 lecturers (19.2%). The majority of researchers indicated that they were familiar with the concept of COI (88.9%), and they agreed that the existence of COI should be disclosed by all authors (84.5%). About 33.2% of the study participants did not know if their institution had a policy for COI. About half of the participants (48.70%) believed that disclosure is the only way for the management of COI. However, only 41.7% of them ( = 113) indicated that they had disclosed COI in their published research. Finally, participants who have a collaboration with the industry showed a significantly lower tendency to disclose their COI than those who do not have any partnership with the industry (OR = 0.471, = 0.017). The majority of the pharmacy researchers from the MENA region are familiar with the principles of COI, but a lower percentage of them disclose their COI in their published research. Efforts should be made to educate researchers about the importance of disclosing COI, which might reduce the potential of bias in their published research.

摘要

由于制药行业的影响,文献显示在药物有效性和功效的研究中存在一些偏差。因此,研究人员对利益冲突(COI)的理解至关重要,且可能会影响科学研究的质量。所以,在本研究中,我们旨在评估中东和北非(MENA)地区药学研究人员对利益冲突的认知和看法,以及影响他们披露利益冲突的因素。在这项横断面研究中,我们对来自MENA地区的药学研究人员进行了便利抽样调查,以了解他们对利益冲突原则的认知和看法。问卷分为三个主要部分。第一部分评估研究参与者的人口统计学信息;第二部分评估研究人员在处理利益冲突方面的认知和做法;最后,第三部分评估参与者对利益冲突的看法。问卷上传至谷歌表单电子平台,并通过研究参与者的专业电子邮件分发给他们。最后,采用逻辑分析来评估影响研究参与者披露利益冲突的预测因素。共有271名药学研究人员参与了本研究。研究人员按学术职称分布如下:63名教授(23.3%)、59名副教授(21.8%)、97名助理教授(35.8%)和52名讲师(19.2%)。大多数研究人员表示他们熟悉利益冲突的概念(88.9%),并且他们同意所有作者都应该披露利益冲突的存在(84.5%)。约33.2%的研究参与者不知道他们的机构是否有利益冲突政策。约一半的参与者(48.70%)认为披露是管理利益冲突的唯一途径。然而,其中只有41.7%的人(n = 113)表示他们在已发表的研究中披露了利益冲突。最后,与行业有合作的参与者披露利益冲突的倾向明显低于那些与行业没有任何合作关系的参与者(OR = 0.471,P = 0.017)。MENA地区的大多数药学研究人员熟悉利益冲突原则,但在已发表的研究中披露利益冲突的比例较低。应该努力教育研究人员披露利益冲突的重要性,这可能会减少他们已发表研究中存在偏差的可能性。

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