Zhou Wenlin, Weng Yujie, Liu Qian, Wang Chonglong, Zhang Yu-Qing, Zhang Xing, Ye Aihong
Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Department of Biological Sciences, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Front Microbiol. 2023 Mar 7;14:1074892. doi: 10.3389/fmicb.2023.1074892. eCollection 2023.
Type II diabetes (T2D) is a global epidemic disease with an increased incidence and prevalence. Gut microbiota plays an important role in controlling T2D development. Dietary administration of prebiotics, probiotics, and drugs, including metformin, showed the regulatory impact on the change of gut microbiota, which is associated with the improvement of glucose tolerance. In this study, silk sericin was manufactured into hydrolyzed sericin peptide (HSP) powders as a dietary additive to investigate the effect on the gut microbiota of T2D model rats. The results indicated that the HSP-augmented dietary administration lowers the fast glucose level of diabetic rats, and HSP augmentation induces a change in the gut microbiota composition of T2D model rats toward the normal rats. Some key taxa, including , were suggested to be involved in controlling T2D development. This finding provides new insight into developing sericin as functional food or therapeutic prebiotics against T2D in clinical practice.
2型糖尿病（T2D）是一种发病率和患病率不断上升的全球性流行病。肠道微生物群在控制T2D发展中起着重要作用。益生元、益生菌和包括二甲双胍在内的药物的饮食给药显示出对肠道微生物群变化的调节作用，这与葡萄糖耐量的改善有关。在本研究中，将丝胶蛋白制成水解丝胶蛋白肽（HSP）粉末作为饮食添加剂，以研究其对T2D模型大鼠肠道微生物群的影响。结果表明，补充HSP的饮食给药降低了糖尿病大鼠的空腹血糖水平，并且HSP补充诱导T2D模型大鼠的肠道微生物群组成向正常大鼠转变。一些关键分类群，包括 ，被认为参与控制T2D的发展。这一发现为临床实践中开发丝胶蛋白作为抗T2D的功能性食品或治疗性益生元提供了新的见解。
