Li Xin-Yu, Shen Liang, Ji Hong-Fang
Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
Diabetes Metab Syndr Obes. 2019 May 17;12:771-778. doi: 10.2147/DMSO.S203239. eCollection 2019.
possesses therapeutic effects for type 2 diabetes (T2D), while its action mechanisms remain to be elucidated. In view of the pathogenic associations between gut microbiota and T2D, we explored the effect of astragalus on gut-microbiota composition of T2D mice. Modulation effects of astragalus on gut microbiota of T2D-model mice were assessed by 16S rRNA gene sequencing. Inhibited blood-glucose and body-weight levels of T2D mice by astragalus were accompanied by gut microbiota-composition alteration. Astragalus administration significantly increased gut-microbiota richness and diversity in T2D mice and significantly altered the abundance of several bacterial taxa, inducing increased abundance of and . PICRUSt software revealed the relationship between astragalus and T2D. Due to previously reported decreased gut-microbiota richness and diversity and reduced abundance of key species of and , more studies are encouraged to explore the contribution of gut-microbiota alteration by astragalus to its anti-T2D effect.
对2型糖尿病（T2D）具有治疗作用，但其作用机制仍有待阐明。鉴于肠道微生物群与T2D之间的致病关联，我们探讨了黄芪对T2D小鼠肠道微生物群组成的影响。通过16S rRNA基因测序评估黄芪对T2D模型小鼠肠道微生物群的调节作用。黄芪抑制T2D小鼠的血糖和体重水平，同时伴有肠道微生物群组成的改变。给予黄芪显著增加了T2D小鼠肠道微生物群的丰富度和多样性，并显著改变了几种细菌类群的丰度，导致 和 的丰度增加。PICRUSt软件揭示了黄芪与T2D之间的关系。由于先前报道肠道微生物群的丰富度和多样性降低以及 和 关键物种的丰度减少，鼓励进行更多研究以探索黄芪引起的肠道微生物群改变对其抗T2D作用的贡献。
