子宫内膜异位症与微生物组的双向关系。
The bidirectional relationship between endometriosis and microbiome.
机构信息
Endometriosis Ultrasound and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Sydney, NSW, Australia.
University of New South Wales Microbiome Research Centre, St. George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
出版信息
Front Endocrinol (Lausanne). 2023 Mar 7;14:1110824. doi: 10.3389/fendo.2023.1110824. eCollection 2023.
Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis inflammatory pathways. The dysbiosis seen in endometriosis is thought to be both causative and a consequence of the pathogenesis. Gut, peritoneal fluid and female reproductive tract microbiota has been studied to understand if there are any microbiome signatures specific to endometriosis. New research on how to manipulate the microbiome for better detection and treatment of endometriosis is emerging.
多年来，人们提出了许多不同的子宫内膜异位症发病机制理论。目前也认为它是一种慢性炎症状态，免疫功能障碍在其发展中的作用已得到证实。越来越多的证据支持微生物组在子宫内膜异位症形成和进展中的作用 炎症途径。子宫内膜异位症中观察到的菌群失调被认为既是发病机制的原因，也是结果。已经研究了肠道、腹腔液和女性生殖道微生物群，以了解是否存在特定于子宫内膜异位症的微生物组特征。关于如何操纵微生物组以更好地检测和治疗子宫内膜异位症的新研究正在出现。
Zotero 插件