红细胞分布宽度与心力衰竭患者3个月再入院风险的关联：一项回顾性队列研究。
Association of red cell distribution width with the risk of 3-month readmission in patients with heart failure: A retrospective cohort study.
作者信息
Gu Fang, Wu Han, Jin Xiaoli, Kong Cheng, Zhao Wenyan
机构信息
Center for Reproductive Medicine, Department of Pediatrics, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Department of Clinical Laboratory Medicine, Sir Run Run Shaw Hospital Xiasha Campus, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Front Cardiovasc Med. 2023 Mar 7;10:1123905. doi: 10.3389/fcvm.2023.1123905. eCollection 2023.
BACKGROUND
In recent years, red cell distribution width (RDW) has been found to be associated with the prognosis of patients with heart failure (HF) in Western countries. However, evidence from Asia is limited. We aimed to investigate the relationship between RDW and the risk of 3-month readmission in hospitalized Chinese HF patients.
METHODS
We retrospectively analyzed HF data from the Fourth Hospital of Zigong, Sichuan, China, involving 1,978 patients admitted for HF between December 2016 and June 2019. The independent variable in our study was RDW, and the endpoint was the risk of readmission within 3 months. This study mainly used a multivariable Cox proportional hazards regression analysis. Smoothed curve fitting was then used to assess the dose-response relationship between RDW and the risk of 3-month readmission.
RESULTS
In the original cohort of 1,978 patients with HF (42% male and 73.1% aged ≥70 years), 495 patients (25.0%) were readmitted within 3 months after discharge. Smoothed curve fitting showed a linear correlation between RDW and the risk of readmission within 3 months. In the multivariable-adjusted model, every 1% increase in RDW was associated with a 9% increased risk of readmission within 3 months (hazard ratio = 1.09, 95% confidence interval: 1.00-1.15; < 0.005).
CONCLUSIONS
A higher RDW value was significantly associated with a greater risk of 3-months readmission in hospitalized patients with HF.
背景
近年来，在西方国家发现红细胞分布宽度（RDW）与心力衰竭（HF）患者的预后相关。然而，来自亚洲的证据有限。我们旨在研究RDW与中国住院HF患者3个月再入院风险之间的关系。
方法
我们回顾性分析了中国四川省自贡市第四医院的HF数据，涉及2016年12月至2019年6月期间因HF入院的1978例患者。我们研究中的自变量是RDW，终点是3个月内再入院的风险。本研究主要采用多变量Cox比例风险回归分析。然后使用平滑曲线拟合来评估RDW与3个月再入院风险之间的剂量反应关系。
结果
在最初的1978例HF患者队列中（42%为男性，73.1%年龄≥70岁），495例患者（25.0%）在出院后3个月内再次入院。平滑曲线拟合显示RDW与3个月内再入院风险之间存在线性相关性。在多变量调整模型中，RDW每增加1%，3个月内再入院风险增加9%（风险比=1.09，95%置信区间：1.00-1.15；P<0.005）。
结论
较高的RDW值与住院HF患者3个月再入院风险显著相关。
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