School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran.
Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Fundam Clin Pharmacol. 2023 Oct;37(5):900-909. doi: 10.1111/fcp.12896. Epub 2023 Mar 30.
Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC.
膀胱癌（BC）是一种常见的泌尿生殖系统恶性肿瘤，在全球范围内具有较高的死亡率。尽管最近有了治疗方法，但复发率仍然很高，这凸显了需要一种新的策略来降低 BC 细胞的进展。槲皮素是一种类黄酮化合物，具有有前途的抗癌特性，可用于管理各种恶性肿瘤，如 BC。本综述总结了槲皮素在抗癌活性方面的细胞和分子机制。研究结果表明，槲皮素可防止人膀胱癌细胞系的增殖，促进 BIU-87 细胞的凋亡，降低 p-P70S6K 的表达，并通过 p-AMPK 诱导细胞凋亡。此外，槲皮素通过 AMPK/mTOR 级联抑制肿瘤生长，并通过触发 DNA 损伤来阻止人膀胱癌细胞的集落形成。研究这篇综述文章将有助于研究人员更好地理解槲皮素在预防和治疗膀胱癌方面的功能作用。
