Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Motamed Cancer Institute, Breast Cancer Research Center, ACECR, Tehran, Iran.
Pathol Res Pract. 2024 Aug;260:155374. doi: 10.1016/j.prp.2024.155374. Epub 2024 May 29.
The escalating global incidence of cancer, which results in millions of fatalities annually, underscores the pressing need for effective pharmacological interventions across diverse cancer types. Long noncoding RNAs (lncRNAs), a class of RNA molecules that lack protein-coding capacity but profoundly impact gene expression regulation, have emerged as pivotal players in key cellular processes, including proliferation, apoptosis, metastasis, cellular metabolism, and drug resistance. Among natural compounds, quercetin, a phenolic compound abundantly present in fruits and vegetables has garnered attention due to its significant anticancer properties. Quercetin demonstrates the ability to inhibit cancer cell growth and induce apoptosis-a process often impaired in malignant cells. In this comprehensive review, we delve into the therapeutic potential of quercetin in cancer treatment, with a specific focus on its intricate interactions with lncRNAs. We explore how quercetin modulates lncRNA expression and function to exert its anticancer effects. Notably, quercetin suppresses oncogenic lncRNAs that drive cancer development and progression while enhancing tumor-suppressive lncRNAs that impede cancer growth and dissemination. Additionally, we discuss quercetin's role as a chemopreventive agent, which plays a crucial role in mitigating cancer risk. We address research challenges and future directions, emphasizing the necessity for in-depth mechanistic studies and strategies to enhance quercetin's bioavailability and target specificity. By synthesizing existing knowledge, this review underscores quercetin's promising potential as a novel therapeutic strategy in the ongoing battle against cancer, offering fresh insights and avenues for further investigation in this critical field.
癌症在全球的发病率不断上升，每年导致数百万人死亡，这突显了在不同癌症类型中需要有效的药物干预。长链非编码 RNA（lncRNA）是一类缺乏蛋白质编码能力但对基因表达调控有深远影响的 RNA 分子，已成为关键细胞过程（包括增殖、凋亡、转移、细胞代谢和耐药性）中的关键参与者。在天然化合物中，槲皮素是一种大量存在于水果和蔬菜中的酚类化合物，由于其显著的抗癌特性而受到关注。槲皮素能够抑制癌细胞生长并诱导细胞凋亡——这一过程在恶性细胞中经常受到损害。在这篇全面综述中，我们深入探讨了槲皮素在癌症治疗中的治疗潜力，特别关注其与 lncRNA 的复杂相互作用。我们探讨了槲皮素如何调节 lncRNA 的表达和功能以发挥其抗癌作用。值得注意的是，槲皮素抑制促进癌症发展和进展的致癌 lncRNA，同时增强抑制癌症生长和扩散的肿瘤抑制 lncRNA。此外，我们还讨论了槲皮素作为化学预防剂的作用，它在减轻癌症风险方面起着至关重要的作用。我们解决了研究挑战和未来方向，强调需要进行深入的机制研究和策略来提高槲皮素的生物利用度和靶向特异性。通过综合现有知识，本综述强调了槲皮素作为一种新型治疗策略在与癌症斗争中的有前途的潜力，为这一关键领域提供了新的见解和进一步研究的途径。
