Department of Chemistry, VSSUT, Burla, Sambalpur, India.
Department of 5-yr Integrated Chemistry, Palamuru University, Mabubnagar, Telangana, India.
Chirality. 2023 Aug;35(8):477-497. doi: 10.1002/chir.23559. Epub 2023 Mar 24.
Accounts on the recent (over the past 10 years) catalytic asymmetric hydrogenation reaction-based achievements with different catalysts to generate natural products and synthetic targets such as fragrances, pharmaceutical agents, and agrochemicals are mentioned in this present concise review. Mechanistic steps, chemoselectivity with higher functional group tolerance by employing transition metal-based chiral catalysts (Ir-, Rh-, Ni-, Ru-, Fe-, Mn-, Pd-, Co-, and Zn-based organometallic chiral complexes), and biocatalysts and their importance on the genesis of chirality coupled with higher turnover numbers are also described.
本综述提到了过去 10 年来不同催化剂在催化不对称氢化反应方面的最新成就，用于生成天然产物和合成目标，如香料、药物试剂和农用化学品。本文还介绍了反应的机理步骤、采用基于过渡金属的手性催化剂（铱、铑、镍、钌、铁、锰、钯、钴和锌的有机金属手性配合物）的化学选择性和对更高功能基团的耐受性，以及生物催化剂及其在手性起源和更高周转率方面的重要性。
