Department of Burn and Plastic Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Int Wound J. 2023 Oct;20(8):2981-2988. doi: 10.1111/iwj.14165. Epub 2023 Mar 24.
The purpose of this study is to investigate the effect of hydrocolloid dressing combined with low molecular weight heparin calcium on scar hyperplasia in burn patients with venous thromboembolism. A retrospective analysis was made on 98 patients with burns complicated with venous thromboembolism in Renmin Hospital, Hubei University of Medicine from January 2020 to April 2021. According to different treatment methods, they were divided into a control group (48 cases) and a research group (50 cases), who were given low molecular weight heparin calcium combined with routine treatment and hydrocolloid dressing on the basis of the control group. The wound healing time, dressing change times and infection symptom regression time in the study group were significantly lower than those in the control group (P < .05). After the intervention, the degree of wound pain in both groups was reduced, and the degree of wound pain in the study group was significantly lower than that in the control group, with statistical significance (P < .05). Fibrinogen, activated partial thromboplastin (APPT), D-dimer, fibrinolytic degradation products, prothrombin time and activated partial prothrombin time of the two groups were all improved. The degree of scar hyperplasia in both groups was improved, and the degree of scar hyperplasia in the study group was significantly better than that in the control group, and the difference was statistically significant (P>.05). Complications in the study group were lower than those in the control group, and the difference was statistically significant (P < .05). The hydrocolloid dressing combined with low molecular weight heparin calcium can effectively shorten the wound healing time and infection symptom regression time of burn patients with venous thromboembolism, reduce the number of dressing changes, reduce the degree of pain, have no influence on coagulation function, reduce the degree of scar, and reduce the incidence of complications.
本研究旨在探讨水胶体敷料联合低分子肝素钙对烧伤合并静脉血栓栓塞症患者瘢痕增生的影响。回顾性分析 2020 年 1 月至 2021 年 4 月在湖北医药学院人民医院烧伤合并静脉血栓栓塞症的 98 例患者，根据不同治疗方法分为对照组（48 例）和研究组（50 例），对照组在常规治疗的基础上加用低分子肝素钙，研究组在此基础上加用水胶体敷料。研究组的创面愈合时间、换药次数和感染症状消退时间均明显低于对照组（P<.05）。干预后两组创面疼痛程度均降低，且研究组明显低于对照组，差异有统计学意义（P<.05）。两组纤维蛋白原、活化部分凝血活酶时间（APTT）、D-二聚体、纤维蛋白降解产物、凝血酶原时间和活化部分凝血酶原时间均改善，两组瘢痕增生程度均改善，且研究组明显优于对照组，差异有统计学意义（P>.05）。研究组并发症发生率低于对照组，差异有统计学意义（P<.05）。水胶体敷料联合低分子肝素钙可有效缩短烧伤合并静脉血栓栓塞症患者的创面愈合时间和感染症状消退时间，减少换药次数，减轻疼痛程度，对凝血功能无影响，降低瘢痕增生程度，降低并发症发生率。
