National Medical Research Center of Cardiology, 121552 Moscow, Russia.
I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Tomography. 2023 Feb 27;9(2):529-540. doi: 10.3390/tomography9020043.
The present study evaluated the cortical activation during emotional information recognition.
The study group included 16 patients with depression, and 16 healthy subjects were enrolled as a control group. Patients received eight weeks of antidepressant therapy. Functional MRI evaluated the cortical activation twice in the patient group and once in the control group. The fMRI task processed the emotional information with face demonstration from the PennCNP test battery.
During the processing of emotional information, patients showed activation in the middle and the inferior frontal gyri, the fusiform gyrus, and the occipital cortex. After treatment, patients showed a significant decrease in the frontal cortex activation for negative face demonstration and no frontal activation for positive emotion recognition. The left superior temporal gyrus activation zone appeared in patients after treatment and in the control group. Healthy subjects showed more intense frontal cortex activation when processing neutral emotions and less when showing happy and sad faces. Activation zones in the amygdala and the insula and deactivation zones in the posterior cingulate cortex were revealed in the controls.
This study confirms the hypothesis that anomalies in the processing of emotional stimuli can be a sign of a depressive disorder.
本研究评估了情绪信息识别过程中的皮质激活。
研究组包括 16 名抑郁症患者，16 名健康受试者作为对照组。患者接受了八周的抗抑郁治疗。功能磁共振成像（fMRI）在患者组中进行了两次评估，在对照组中进行了一次评估。fMRI 任务使用来自 PennCNP 测试库的面部演示处理情绪信息。
在处理情绪信息时，患者在前额中回和额下回、梭状回和枕叶皮层显示出激活。治疗后，患者对负性面孔演示的额皮质激活显著降低，对正性情绪识别无额皮质激活。治疗后患者和对照组的左侧颞上回激活区出现。健康受试者在处理中性情绪时表现出更强的额皮质激活，而在显示快乐和悲伤面孔时则较少。对照组显示杏仁核和岛叶的激活区和后扣带回皮质的去激活区。
本研究证实了这样一种假设，即情绪刺激处理异常可能是抑郁症的一个标志。
